The Effect of Different Interfaces on the Aerosol Delivery with Vibrating Mesh Nebulizer During Noninvasive Positive Pressure Ventilation.

Journal of Aerosol Medicine and Pulmonary Drug Delivery
Wei TanJian Kang

Abstract

Background: The effect of different interfaces on the aerosol delivery with vibrating mesh nebulizer during noninvasive positive pressure ventilation (NIV) is not clear. Materials and Methods: Noninvasive ventilator and four interfaces were connected to IngMar ASL 5000 lung simulator. Meanwhile, the vibrating mesh nebulizer was connected to a ventilator circuit to simulate the nebulization during noninvasive ventilation. The nebulizer position was placed at proximal position (near the mask) and distal position (15 cm away from the mask); the inspiratory positive airway pressure (IPAP) and the expiratory positive airway pressure (EPAP) were set to 16/4, 16/8, 20/4, and 20/8 cmH2O, respectively. The aerosol was collected through a disposable filter placed between the simulated lung and the mask, after which the aerosol delivery was calculated. Meanwhile, we recorded the inspiratory tidal volume and the mean inspiratory flow. Results: The aerosol delivery varied between 1.7% ± 0.0% and 21.1% ± 1.1%. Only when EPAP was set to 4 cmH2O, the statistical difference in aerosol delivery was observed be...Continue Reading

References

Sep 16, 2003·Critical Care Medicine·Guilherme P P SchettinoRobert M Kacmarek
Jan 24, 2004·The European Respiratory Journal·E SaatciJ Moxham
Jun 2, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Daniella Cunha BrandaoArmele Dornelas de Andrade
Jul 21, 2009·Lancet·Stefano Nava, Nicholas S Hill
Jul 29, 2010·The Journal of Pharmacy and Pharmacology·Mohamed Ea AbdelrahimHenry Chrystyn
May 15, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Bing DaiHong-wen Zhao
Feb 13, 2014·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Jean-Bernard MichotteGregory Reychler
Jul 23, 2014·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Nabile BoukhettalaL Vecellio
Oct 18, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Stephen W Stein, Charles G Thiel
Sep 2, 2017·The European Respiratory Journal·Bram RochwergSuhail Raoof
Nov 2, 2017·Respiratory Care·Ahmed S BaHammamSeithikurippu R Pandi-Perumal
Jan 19, 2019·Expert Opinion on Drug Delivery·Gregory Reychler, Jean-Bernard Michotte
Dec 4, 2019·Handbook of Experimental Pharmacology·Federico LavoriniOmar S Usmani

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