The effect of different oral antibiotics on the gastrointestinal microflora of a wild rodent (Aethomys namaquensis)

Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
S A JohnsonSue Jackson

Abstract

Gut sterilization via the oral administration of antibiotics facilitates physiological studies of the nutritionally important relationship between intestinal microflora and the host. However, the composition of gut flora is extremely variable, and as a result, the efficacy of antibiotics in achieving gut sterilization varies considerably between species. We tested the effectiveness of three antibiotic cocktails in sterilizing the gut of a rodent pollinator, the Namaqua rock mouse (Aethomys namaquensis). The cocktails were (1) streptomycin sulfate and bacitracin (previously used with domestic mice and rats), (2) chloramphenicol and bacitracin (based on antibiotic screening tests performed on faecal flora) and (3) Baytril 10% oral solution (a veterinary antimicrobial agent containing enrofloxacin). We tested for antibiotic inactivation by determining bacterial viability through fluorescence staining of faecal samples. We also tested techniques to maintain sterility during antibiotic treatment without the benefit of a laminar flow cabinet. Antibiotics were administered orally in food and water consumed ad libitum over 4 consecutive days. Antibiotic effectiveness was assessed by culturing anaerobic bacteria from faecal samples coll...Continue Reading

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Citations

May 6, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·S A JohnsonS W Nicolson
Aug 16, 2011·The Journal of Nutritional Biochemistry·Cica VissiennonVeronika Butterweck
Mar 15, 2014·Journal of Personality Assessment·Jarrod A JohnsonScott R Ross
Oct 21, 2016·Applied Microbiology and Biotechnology·Miroslav PopperRadomíra Nemcová
Jun 20, 2012·Journal of Sports Sciences·Masato Kawabata, Clifford J Mallett
Feb 4, 2006·The Journal of Trauma·Kentaro ShimizuHisashi Sugimoto
May 12, 2018·Canadian Journal of Microbiology·G Douglas InglisRichard R E Uwiera
Jan 29, 2019·Current Microbiology·Taha Ahmed BenabbouNour-Eddine Karam
Jul 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kirsten B MoysichJulie A Baker
May 2, 2013·Journal of Proteome Research·Ying ZhaoYulan Wang

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