The effect of different snake venoms and anti-venoms on thrombin clotting time in human plasma

Thrombosis Research
S BuschekR Lowe

Abstract

Crotaline snake species, or pit vipers, are distributed throughout Asia and America. While much is known about the clinical effect of these snake venoms, there is a lack of evidence related to the various anti-venoms available and their effectiveness in reversing the effect of different venoms. This study aimed to determine the interaction of the venoms of the following species: Crotalus unicolor, Crotalus adamanteus, Crotalus vegrandis, Trimeresurus spp, Calloselasma rhodostoma, Bothriechis schlegelii and Agkistrodon and the following anti-venoms: Anticrotalico, Antivipmyn, Antibotropico, Antifidico and SAIMR by evaluating their effect on the thrombin clotting time in human plasma. The interactions of venoms and anti-venoms were evaluated using thrombin clotting time in human plasma. The results demonstrate that Anticrotalico anti-venom was most effective for the Crotalid species (Crotalus unicolor, Crotalus adamanteus, Crotalus vegrandis). Anticrotalico extended the time to clot formation 2.7 fold for Crotalus Unicolor, 3 fold for Crotalus Adamanteus and 4.6 fold for Crotalus Vegrandis. The anti-venoms most efficient in reversing the effect of the Trimeresurus spp venom, were Anticrotalico, Antivipmyn, Antibotropico and Antif...Continue Reading

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Citations

Sep 3, 2014·Toxicon : Official Journal of the International Society on Toxinology·G K IsbisterC B Page
Jun 3, 2021·Toxins·Anant DeshwalSuresh Kumar Thallapuranam

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