The effect of different types of hepatic injury on the estrogen and androgen receptor activity of liver

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
D KahnD H Van Thiel

Abstract

Mammalian liver contains receptors for both estrogens and androgens. Hepatic regeneration after partial hepatectomy in male rats is associated with a loss of certain male-specific hepatic characteristics. In this study we investigated the effects of lesser forms of hepatic injury on the levels of estrogen and androgen receptor activity in the liver. Adult male rats were subjected to portacaval shunt, partial portal vein ligation, hepatic artery ligation, or two-thirds partial hepatectomy. Another group of animals was treated with cyclosporine. At the time of sacrifice the livers were removed and used to determine the estrogen and androgen receptor activity in the hepatic cytosol. A significant reduction (p less than 0.05) in the hepatic cytosolic androgen receptor activity and a slight increase in the estrogen receptor activity occurred following total portosystemic shunting. Partial ligation of the portal vein, which produces a lesser degree of portosystemic shunting, had no effect on the levels of the estrogen and androgen receptor activity present within hepatic cytosol. Cyclosporine-treated animals had significantly greater (p less than 0.01) levels of estrogen receptor activity in the hepatic cytosol compared to vehicle-tr...Continue Reading

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Citations

Mar 1, 1996·Maturitas·P Collins
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S D TadicP K Eagon
Sep 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D H Van ThielE Rosenblum
Jan 1, 1993·Acta Oncologica·S E StrandJ Tennvall
Sep 1, 1991·Digestive Diseases and Sciences·D H Van ThielA Francavilla
Dec 11, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bing HanEric Lagasse

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