The effect of diffusion hardened oxidized zirconium wear debris on cell viability and inflammation--an in vitro study

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
S F RoseV D Pawar

Abstract

Wear debris generation in total joint replacement remains a concern because of its association with aseptic loosening, osteolysis, and ultimately implant failure. In a quest to develop new implant materials with reduced wear and improved biocompatibility a new composition of oxidized Zr2.5Nb alloy; diffusion hardened oxidized zirconium (DHOxZr) has been developed. In this study, we have determined the in vitro biocompatibility of the wear debris of this new composition and compared it to wear debris particles of Ti6Al4V, Cobalt, and CoCr. The cytotoxicity of these particles on fibroblast-like cells (L929) and osteoblast-like cells (SaOS2) was assessed using lactate dehydrogenase and DNA quantification assays. The inflammatory response to these particles was assessed by release of interleukin-1 beta and tumor necrosis factor from macrophage-like cells. The results showed that wear debris generated from DHOxZr was less cytotoxic and elicited a reduced inflammatory response as compared to that of Cobalt or CoCr and might therefore offer a benefit as a joint prosthesis.

References

May 1, 1992·The Journal of Bone and Joint Surgery. British Volume·J M LeeP G Bullough
Feb 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J PfeilschifterG D Roodman
Jul 1, 1986·The Journal of Experimental Medicine·B M ThomsonT J Chambers
Sep 1, 1995·The Journal of Bone and Joint Surgery. American Volume·W J MaloneyH Rubash
Feb 1, 1994·The Journal of Bone and Joint Surgery. American Volume·K J KimH E Rubash
Jun 1, 1993·The Journal of Bone and Joint Surgery. American Volume·D R HaynesD W Howie
Jun 1, 1993·The Journal of Bone and Joint Surgery. American Volume·W J MaloneyD J Schurman
Oct 28, 1999·The Journal of Arthroplasty·L M JazrawiP E Di Cesare
Jun 17, 2003·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·S WilliamsJ Fisher
Dec 4, 2003·The Journal of Bone and Joint Surgery. American Volume·Victoria GoodDan Heuer
Oct 12, 2004·Biomaterials·Eileen Ingham, John Fisher
Dec 7, 2005·Clinical Orthopaedics and Related Research·Robert B BourneVictoria Good
Dec 15, 2007·The Journal of Arthroplasty·Alexander P Sah, John E Ready
Aug 30, 2008·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·P Edward PurdueThomas P Sculco
Feb 10, 2009·The Journal of the American Academy of Orthopaedic Surgeons·Joshua J JacobsMarkus A Wimmer
Apr 3, 2009·The Journal of Bone and Joint Surgery. American Volume·Richard W McCaldenKory D Charron
Sep 22, 2009·Clinical Orthopaedics and Related Research·William G HamiltonJoel Politi

❮ Previous
Next ❯

Citations

Feb 11, 2018·Journal of Biomedical Materials Research. Part a·Furqan A ShahAnders Palmquist
Jun 26, 2020·Frontiers in Cell and Developmental Biology·Li ZhangKoroush Kabir
Nov 29, 2020·The Journal of Arthroplasty·Noah B BonnheimLisa A Pruitt
May 9, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Stefania PaganiPaolo Caravaggi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.