PMID: 7035911Jan 1, 1982Paper

The effect of dimethylsulfoxide on the mutagenicity of the hair dye p-phenylenediamine

Mutation Research
C BurnettJ Menkart

Abstract

Published data on the mutagenicity of the oxidative hair dye intermediate p-phenylenediamine in the Ames test are conflicting. The work reported here resolves the discrepancies, showing that the activity of p-phenylenediamine in the Ames Salmonella/microsome test is markedly influenced by the use of dimethylsulfoxide as solvent, and by the age of the solution prior to plating. Thus, aqueous solutions of p-phenylenediamine are non-mutagenic; fresh solutions in DMSO are equally non-mutagenic, but become highly active on standing at room temperature for 4 hr. These results suggest the need for caution in the choice of solvents and tight controls in the execution of the test.

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·E Yamasaki, B N Ames
Nov 1, 1979·Cancer Letters·M DegawaY Hashimoto
Apr 1, 1977·Mutation Research·T YahagiT Sugimura
Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·B N AmesE Yamasaki

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Citations

Jan 5, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Eyyüp RencüzoğullariMehmet Arslan
Jan 11, 2012·Environmental Science and Pollution Research International·Hongxia Xiong, Qixing Zhou
Jul 1, 1988·Mutation Research·D M Logan, M F Salamone
Jul 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J LeM Kramer
Nov 1, 1995·Toxicology Letters·K T ChungM W Chou
Mar 17, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gerhard J NohynekHerve Toutain
Dec 2, 2004·Mutation Research·Larry D ClaxtonSarah H Warren
Dec 30, 2014·Regulatory Toxicology and Pharmacology : RTP·Alexander P HardingMichael Kranz
Feb 27, 2018·Environmental and Molecular Mutagenesis·Krista L DoboMichelle O Kenyon
Jan 1, 1983·Annals of the New York Academy of Sciences·M J Prival
Jan 1, 1987·Environmental and Molecular Mutagenesis·R K BrodbergR C Woodruff
Jan 1, 1985·Environmental Mutagenesis·E R NestmannT R Harrington

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