PMID: 101932Nov 1, 1978Paper

The effect of dinitrochlorobenzene (DNCB) on dimethylbenzathracene (DMBA) carcinogenesis on hamster buccal pouch

Oral Surgery, Oral Medicine, and Oral Pathology
J B Murphy, J Giunta

Abstract

DNCB is an antigen that stimulates the cell-mediated response in a sensitized host. The purpose of this study was to define the effect DNCB would have on a standard model system for oral carcinogenesis, theorizing that tumorgenesis would be delayed or inhibited. Fifty-six Syrian hamsters were divided into four groups. In group A (DNCB/DMBA), the right buccal pouch of twenty animals was treated with 2% DNCB in orabase, twice a week, and 0.5% DMBA, three times a week, for 10 weeks. In group B, twenty animals received DMBA only. In group C, six animals received DMBA in Orabase. In group D, ten animals received DNCB in Orabase only. The animals were killed at 6, 12, 16, and 20 weeks. The results indicate that there were no differences in the latent period or in the histologic characteristics of the epidermoid carcinomas that developed. However, there was sensitization of the buccal pouch in pouches painted with DNCB, in that gross and histologic evidence of a delayed sensitivity reaction was demonstrated.

References

Apr 1, 1977·Oral Surgery, Oral Medicine, and Oral Pathology·E Eisenberg, G Shklar
May 1, 1976·Journal of Oral Pathology·A R Mohammad, H H Mincer
Mar 1, 1971·Oral Surgery, Oral Medicine, and Oral Pathology·J Giunta, G Shklar

Citations

Oct 1, 1989·Journal of Biomedical Materials Research·W C FoongM Mezei
Jun 1, 1981·Journal of Oral Pathology·J W Eveson
Dec 1, 1984·Scandinavian Journal of Dental Research·E E Ahlfors, P A Larsson

Related Concepts

Administration, Topical
Benz(a)Anthracenes
Carcinomatosis
Cheek Structure
Dinitrochlorobenzene
Cricetus
Cellular Immune Response
Variolation
Mesocricetus
Malignant Neoplasm of Mouth

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