The effect of Diprivan (propofol) on phosphorylcholine surfaces during cardiopulmonary bypass--an in vitro investigation

Perfusion
Gerard J MyersRenRen Johnstone

Abstract

It is well known that extracorporeal surfaces have the ability to bind such drugs as fentanyl, nitroglycerine and propofol. Adsorption of the injectable anesthetic agent Diprivan (propofol) onto uncoated and heparin-coated extracorporeal surfaces during cardiopulmonary bypass (CPB) has been previously investigated; however, propofol adsorption onto synthetic-coated extracorporeal surfaces has not been published previously. The focus of this investigation was on the interaction of propofol and the synthetic biomimetic coating from the Sorin Group called Mimesys (phosphorylcholine (PC)). A randomized series of six in vitro experiments were done with propofol using both PC-coated circuits without arterial filters and those with arterial filters. The circuits were identical in all experiments and priming remained the same, with 750 mls of normal saline and 1250 mls of fresh bovine blood (hematocrit 41.0 +/- 1.0%). After circulation and collection of baseline samples, the first (low) dose of 4 mg (4000 mcg) of Diprivan 1% was added to the perfusate, followed by the second (high) dose of 40 mg (40,000 mcg) and the final challenge (extreme dose) of 356 mg (356,000 mcg) of Diprivan. Drug assay was done by an independent laboratory, usi...Continue Reading

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Citations

Mar 20, 2015·Anesthesia and Analgesia·Aaron E BarryMartin J London
Nov 11, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Benjamin HohlfelderJeremy R Degrado
Oct 4, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hergen BuscherPriya Nair
Sep 24, 2019·The Annals of Pharmacotherapy·Mitulkumar PatelJohn Papadopoulos
Jul 9, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Dana BakdachIbrahim Hassan
May 14, 2021·The International Journal of Artificial Organs·Kelsey L BrowderKomal A Pandya
Jun 3, 2021·Membranes·Pavel SukIvan Čundrle
Jul 20, 2021·Current Anesthesiology Reports·Christopher Uhlig, Jakob Labus
Aug 21, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Michael T KuntzViviane G Nasr

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