The effect of dissolved oxygen on the susceptibility of blood

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Avery J L BermanG B Pike

Abstract

It has been predicted that, during hyperoxia, excess O2 dissolved in arterial blood will significantly alter the blood's magnetic susceptibility. This would confound the interpretation of the hyperoxia-induced blood oxygenation level-dependent signal as arising solely from changes in deoxyhemoglobin. This study, therefore, aimed to determine how dissolved O2 affects the susceptibility of blood. We present a comprehensive model for the effect of dissolved O2 on the susceptibility of blood and compare it with another recently published model, referred to here as the ideal gas model (IGM). For validation, distilled water and samples of bovine plasma were oxygenated over a range of hyperoxic O2 concentrations and their susceptibilities were determined using multiecho gradient echo phase imaging. In distilled water and plasma, the measured changes in susceptibility were very linear, with identical slopes of 0.062 ppb/mm Hg of O2. This change was dramatically less than previously predicted using the IGM and was close to that predicted by our model. The primary source of error in the IGM is the overestimation of the volume fraction occupied by dissolved O2. Under most physiological conditions, the susceptibility of dissolved O2 can be...Continue Reading

References

Mar 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J W Severinghaus
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K K KwongR Turner
Jun 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BandettiniJ S Hyde
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S OgawaK Ugurbil
Apr 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S OgawaP Glynn
Dec 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H Gudbjartsson, S Patz
Apr 3, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W M SpeesJ J Ackerman
Apr 1, 1936·Proceedings of the National Academy of Sciences of the United States of America·L Pauling, C D Coryell
Jul 17, 2007·NeuroImage·Peter A ChiarelliPeter Jezzard
Dec 25, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael C LanghamFelix W Wehrli
Jun 16, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael C LanghamFelix W Wehrli
Jan 22, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Simon RobinsonSiegfried Trattnig
May 25, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David T PilkintonRavinder Reddy
Aug 23, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Cheng LiFelix W Wehrli
Sep 29, 2011·NeuroImage·Christian Schwarzbauer, Ralf Deichmann
Dec 14, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Varsha JainFelix W Wehrli
Nov 23, 2012·Journal of Magnetic Resonance Imaging : JMRI·David K W YeungJing Yuan
Apr 8, 2014·Journal of Magnetic Resonance·Matthias C WaplerUlrike Wallrabe

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Citations

Dec 2, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Avery J L Berman, G Bruce Pike
Jul 1, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yuhan MaG Bruce Pike
Dec 3, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yuhan MaG Bruce Pike

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