PMID: 9539078Apr 16, 1998Paper

The effect of dobutamine on distal colon ischaemia in the pig

Intensive Care Medicine
M BjörckU Haglund

Abstract

To test the hypotheses that dobutamine increases intestinal blood flow, it reduces mucosal acidosis and it prevents mucosal injury in an experimental porcine model of distal colonic ischaemia. And the hypothesis that mannitol prevents reperfusion injury. Randomised animal experiment. University Hospital, Department of Experimental Research. Twenty-four pigs. Twenty-one pigs were subjected to 7 h of controlled non-occlusive intestinal ischaemia of the distal colon, consisting of an occlusion of the inferior mesenteric artery (IMA) and a constriction of the superior mesenteric artery (SMA). At 3.5 h six pigs were treated with dobutamine, six with mannitol (0.18 g/kgBW), six with dobutamine and mannitol and three served as controls. Three non-ischaemic pigs were treated with dobutamine. All animals were haemodynamically stable throughout the experiment. There was no difference in any variable between the animals treated with mannitol and those not treated. The ischaemic dobutamine-treated animals increased their cardiac output (CO) by 14% compared to baseline and by 59% compared to controls. The median final dosage of dobutamine was 13.2 micrograms/kg per min (range 8.6-25.8). The blood flow in the restricted SMA, the intramucosal...Continue Reading

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Citations

Jun 5, 2004·Pediatric Emergency Care·Leonard E Swischuk
May 25, 2011·World Journal of Gastrointestinal Pathophysiology·Yan-Fang GuanMarshall H Montrose
Nov 26, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·T BlockT K Nilsson
May 29, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Stefan AcostaMartin Björck

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