PMID: 11925896Apr 3, 2002Paper

The effect of dopamine on serum lipid concentration after propofol administration

Masui. The Japanese journal of anesthesiology
Takashi KimuraOsami Takano

Abstract

Propofol in emulsion formulation is widely used for operation and sedation in ICU. We retrospectively investigated the effect of dopamine on post-operative serum lipid concentrations after propofol administration. Twenty three patients with ASA physical status I or II scheduled for elective operations were enrolled in this study; 15 patients in the non-dopamine administration group (Group P) and 8 patients in the dopamine administration group (Group Dopa-P). We measured triglyceride (TG), total cholesterol (T-chol) pre-operatively, post-operatively and on post-operative day 1 and AST, ALT preoperatively and on post-operative day 1. Serum TG concentration increased significantly in post-operative measurements in Group-P (P < 0.05). But there was no significant change in TG in Group Dopa-P. Serum T-chol concentration decreased significantly post-operatively and on post-operative day 1 in both groups (P < 0.05). Serum AST and ALT concentrations increased significantly on post-operative day 1 (P < 0.05). With 10% fat infusion rates below 0.1 mg.kg-1.hr-1 (equal to propofol 10 mg.kg-1.hr-1), serum lipid concentration did not increase. But our results suggest that the serum TG concentration may increase significantly post-operatively...Continue Reading

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