PMID: 8977512Dec 1, 1996Paper

The effect of drug therapy on long-term outcome of childhood asthma: a possible preview of the international guidelines

The Journal of Allergy and Clinical Immunology
P König, J Shaffer

Abstract

International guidelines classify childhood asthma as mild, moderate, and severe and recommend treatment with "as needed" bronchodilators, cromolyn sodium, and inhaled corticosteroids, respectively. Recently, some investigators proposed inhaled corticosteroids as first-line therapy to avoid possible irreversible airway obstruction. This article describes a retrospective study assessing the effect of the guidelines' approach on the long-term outcome of childhood asthma and the possible effect of delaying initiation of administration of corticosteroids. A retrospective review was performed on the charts of 175 children, and an end-of-study questionnaire plus results of spirometry completed the data. The mean age at start of study was 6.5 years, and the children were followed up for 2.2 to 16.8 years (mean, 8.4 years). Treatments included bronchodilators as needed only (patients with mild asthma), cromolyn sodium (patients with moderate asthma), and inhaled corticosteroids (patients with severe asthma). Frequency of symptoms, unscheduled doctors' visits, emergency department visits, hospitalizations, and missed school days decreased for the whole group. Statistically significant between-treatment differences favored both antiinfla...Continue Reading

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