The effect of dutasteride on microscopic and macroscopic changes of testosterone replacement treatment on prostate tissue

Andrologia
Mehmet Akif DiriRecep Büyükalpelli

Abstract

Testosterone replacement therapy has a growing interest in daily practice; however, debates on its safety for prostate cancer still continue. Dutasteride-a 5α-reductase inhibitor-was shown to be effective in preventing prostate cancer. We therefore aimed to evaluate the effect of testosterone replacement therapy and dutasteride treatment on prostate tissue in castrated rats. Rats were randomised in four groups after bilateral orchidectomy as follows: Group I received testosterone + dutasteride, Group II received only testosterone, Group III had no medical treatment, and Group IV was the control group. After 3 months, rats were sacrificed and laboratory and histopathological examinations were performed. In Groups I and II, prostate volume, T and DHT levels were significantly higher compared to Group III and controls. Groups I and II had also significantly greater preneoplastic histopathological signs; however, in intergroup analyses, Group I showed less premalignant changes compared to Group II. We concluded that dutasteride was effective when combined with testosterone therapy in preventing premalignant histopathological changes in prostate tissue. Further evidence is needed to confirm our findings.

References

May 9, 2003·The Urologic Clinics of North America·David G BostwickCory Schlesinger
Jun 26, 2003·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·John K AmoryJ Lisa Tenover
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Richard V ClarkStuart Hobbs
Dec 13, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Olga M CalofShalender Bhasin
Nov 16, 2006·JAMA : the Journal of the American Medical Association·Leonard S MarksPeter S Nelson
May 10, 2007·American Journal of Physiology. Endocrinology and Metabolism·Stephen E BorstThomas J Wronski
Jul 18, 2008·International Journal of Impotence Research·R ShabsighK M Slawin
Apr 2, 2010·The New England Journal of Medicine·Gerald L AndrioleUNKNOWN REDUCE Study Group
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·J Bradley LaytonM Alan Brookhart
Aug 25, 2015·Reviews in Endocrine & Metabolic Disorders·Abdulmaged M TraishMichael Zitzmann
Apr 28, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stacy LoebPär Stattin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Lambertus A Kiemeney, Maarten C Bosland
The New England Journal of Medicine
Laurence Klotz
The New England Journal of Medicine
Silvio Garattini, Vittorio Bertele'
The New England Journal of Medicine
Fritz H Schröder, Monique J Roobol
© 2022 Meta ULC. All rights reserved