The effect of early detection of occult brain metastases in HER2-positive breast cancer patients on survival and cause of death

International Journal of Radiation Oncology, Biology, Physics
Anna NiwińskaMagdalena Murawska

Abstract

The aim of the study is to evaluate disease-free survival, survival from the detection of brain metastases, overall survival, and cause of death in patients with occult brain metastases (Group I) vs. patients with symptomatic brain metastases (Group II). In 80 HER2-positive breast cancer patients, treated with trastuzumab and cytostatic agents for metastatic disease, magnetic resonance imaging screening of the brain was performed, and in 29 patients (36%) occult brain metastasis was detected (Group I). Whole-brain radiotherapy was delivered to Group I. This first group was compared with 52 patients who had symptomatic brain metastases (Group II) and was treated the same way, at the same clinic, during the same time period. Median disease-free survival was 17 months in Group I and 19.9 months in Group II (p = 0.58). The median time interval between the dissemination of the disease and the detection of occult or symptomatic brain metastases was 9 and 15 months, respectively (p = 0.11). When the brain metastases were detected, the median survival was 9 and 8.78 months, respectively (p = 0.80). The median overall survival was 53 and 51 months, respectively (p = 0.94). In the group with occult brain metastases (Group I) 16% of patie...Continue Reading

References

Nov 1, 1979·Cancer·A DiStefanoG R Blumenschein
Jul 1, 1983·Journal of Surgical Oncology·Y T Lee
Sep 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ilka B FuchsGerard Schaller
Jul 11, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K D MillerG W Sledge
Jan 30, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E ShmueliM Inbar
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy U LinEric P Winer
Jul 20, 2005·The Breast : Official Journal of the European Society of Mastology·H J StemmlerV Heinemann
Apr 11, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B C PestalozziUNKNOWN International Breast Cancer Study Group (IBCSG)
Nov 15, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zsolt GabosBassam Abdulkarim
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nancy U Lin, Eric P Winer

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Citations

Sep 13, 2012·Breast Cancer Research and Treatment·Nils D ArvoldBrian M Alexander
Dec 12, 2012·Breast Cancer Research and Treatment·Kenneth R Hess, Francisco J Esteva
Dec 3, 2011·Current Oncology Reports·Joseph A Bovi, Julia White
Oct 1, 2013·The Breast : Official Journal of the European Society of Mastology·Ian E Smith, Gaia Schiavon
Nov 12, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A Tallet
Apr 8, 2015·Neuro-oncology·Shannon PuhallaEdward Neuwelt
Apr 16, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·K I Cao, Y M Kirova
Jul 23, 2014·Cancer Chemotherapy and Pharmacology·Moon Ki ChoiYoung-Hyuck Im
Nov 28, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M J Gil-GilS Villà
Aug 27, 2014·Japanese Journal of Clinical Oncology·Sayaka KubaShinji Ohno
Jan 23, 2016·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Chongjian ZhangShude Cui
Jan 24, 2016·The Breast : Official Journal of the European Society of Mastology·Onder TonyaliUNKNOWN Anatolian Society of Medical Oncology (ASMO)
Jun 26, 2012·Cancer Treatment Reviews·Ankit I MehtaJohn H Sampson
Mar 12, 2015·Future Oncology·Richard J Epstein
Apr 18, 2015·The Breast : Official Journal of the European Society of Mastology·P B De IesoG M Ross
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Cyrus ChargariYoulia M Kirova
Apr 22, 2015·Breast Cancer Research and Treatment·Laura E G WarrenJennifer R Bellon
May 25, 2012·The New England Journal of Medicine·José BaselgaAlessandro Bombonati
Sep 5, 2018·Clinical Nuclear Medicine·Xiaoxia XuZhi Yang
Jan 12, 2012·British Journal of Cancer·A BerghoffR Bartsch
Jan 19, 2019·Nature Reviews. Disease Primers·Achal Singh AchrolSteven D Chang
Feb 29, 2020·Oncotarget·Lola KonialiKyriacos Kyriacou
Nov 2, 2013·Oncology Letters·Troels BechmannAnders Jakobsen
Jul 5, 2018·Journal of Cancer Research and Clinical Oncology·Yi-Jun KimIn Ah Kim
Sep 6, 2020·Current Opinion in Oncology·Lauriane EberstThomas Bachelot
Dec 30, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sara A HurvitzMelody Cobleigh
Jan 12, 2013·Bulletin du cancer·Cécile Le PéchouxFrédéric Dhermain
Oct 30, 2020·Cancer Management and Research·Andria HadjipanteliAnastasia Constantinidou

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