The effect of early virological response in health-related quality of life in HCV-infected patients

Journal of Medical Virology
Lucas C QuarantiniRodrigo A Bressan

Abstract

Twenty-nine HCV-infected patients were treated with pegylated interferon alpha. Diagnosis was based on serum HCV RNA-PCR positive results and liver biopsy. All patients had elevated serum levels of alanine aminotransferase at the time of the study, but liver disease was compensated. Patients were evaluated at baseline treatment and after 4 and 12 weeks of antiviral treatment with the Medical Outcomes Study 36-item Short-Form Health Survey. The Mini-International Neuropsychiatric Interview was used to exclude previous or current psychiatric diagnoses. Both patients and psychiatrists were blind to the HCV RNA status, and serum HCV RNA test results only became available after the visit at week 12. After antiviral treatment, 16 patients (55.2%) were classified as nonresponders and 13 (44.8%) were classified as responders. When compared to nonresponders, responders had a greater improvement in the HRQOL scores for the mental health domain (P < .019). Differences in other domains were not significant. The present study confirms that active viral infection is one possible reason for the poor Health-Related Quality of Life in this population.

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Citations

Nov 19, 2013·Clinics and Research in Hepatology and Gastroenterology·Edna StraussMaria Cristina Dias Teixeira
Jul 17, 2010·General Hospital Psychiatry·Amanda Galvão-de AlmeidaLucas C Quarantini
Sep 13, 2015·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Neila Paula de SouzaCléa Adas Saliba Garbin
Aug 14, 2009·Journal of Viral Hepatitis·G R Foster
Jun 8, 2015·The International Journal on Drug Policy·David WhiteleyAnne Whittaker
Jun 17, 2015·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Kyungeh AnAngela Starkweather
Jul 16, 2011·Journal of Hepatology·Jennifer R KramerHashem B El-Serag
Apr 22, 2014·Journal of Psychosomatic Research·Clarissa Iris Rocha-LeiteLucas C Quarantini
Oct 24, 2014·PloS One·Mychelle Morais-de-JesusLucas C Quarantini
May 29, 2015·PloS One·Glória O OrgeLucas C Quarantini
May 26, 2010·HIV Medicine·L S Briongos FigueroJ M Eiros Bouza

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