The effect of edothelium on the response to propofol on bovine coronary artery rings

Acta Anaesthesiologica Scandinavica
N GacarG Aktürk

Abstract

In this study, the effect of propofol on isolated bovine coronary artery tone was studied in artery rings precontracted with PGF2a. Propofol, in concentrations of 10-6-10-5 M did not change vascular smooth muscle tone, but at high concentrations (10-4-10-1 M) produced relaxation in rings with intact endothelium. In rings denuded of endothelium or treated with methylene blue, propofol produced relaxation at 10-3-10-1 M concentrations, but there was a significant decrease in relaxation compared to endothelium intact rings. In the presence of a calcium agonist (Bay K 8644; 10-5 M), propofol produced constriction in rings denuded of endothelium. These results suggest that high concentrations of propofol may have vasorelaxant effect on bovine coronary artery and that these effects may be due to actions on the endothelium and mediated by calcium channels.

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Citations

Jan 28, 2006·European Journal of Anaesthesiology·E CaliskanH Tufan
Oct 17, 1998·British Journal of Pharmacology·S M Wallerstedt, M Bodelsson
Apr 10, 2002·Critical Care Medicine·Paul E Marik, Gary P Zaloga
Dec 23, 2008·Journal of Neurosurgical Anesthesiology·Kazuhiro ShibuyaTakashi Matsukawa
Feb 26, 2004·Anesthesia and Analgesia·Alexandre OuattaraBruno Riou
Jul 7, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Lukasz J KrzychAndrzej Bochenek
Sep 14, 2007·Veterinary Anaesthesia and Analgesia·Christine BaumgartnerWolf Erhardt
Feb 10, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Sinan GursoyCaner Mimaroglu
Apr 2, 2004·European Journal of Anaesthesiology·A P Klockgether-RadkeG Hellige
Dec 13, 2007·Anesthesiology·Noboru TodaYoshio Hatano
Sep 30, 2014·The Journal of Medical Investigation : JMI·Yoko SakaiHiroshi Kitahata

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