PMID: 2994702Sep 1, 1985Paper

The effect of enalapril on baroreceptor mediated reflex function in normotensive subjects

British Journal of Clinical Pharmacology
J F GiudicelliD Jacolot

Abstract

The effects of enalapril, 20 mg orally, on the responses to baroreflex activation and deactivation by respectively phenylephrine and nitroglycerin were investigated in normotensive subjects on a normal sodium diet, with simultaneous measurement of plasma renin activity (PRA), converting enzyme activity (PCEA), aldosterone and catecholamines. Enalapril, 4 h after administration, lowered artificial blood pressure without modifying heart rate and plasma catecholamines. PCEA was abolished, PRA increased and plasma aldosterone decreased. Enalapril (a) displaced to the left the baroreflex set-point, (b) did not affect baroreflex sensitivity since the slopes of the RR-interval/systolic blood pressure regression lines remained unchanged during both activation and deactivation and (c) did not modify baroreflex efficacy since the maximal RR-interval responses as well as the overall RR-interval-time products to identical blood pressure variations were not modified. Thus, enalapril induced a resetting of the baroreflex, which probably accounts for the lack of reflex tachycardia observed during the drug-induced fall in blood pressure.

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References

Jan 1, 1969·Circulation·J D BristowH S Smyth
Jul 1, 1971·Biochemical Pharmacology·D W Cushman, H S Cheung
Jul 1, 1983·Journal of Cardiovascular Pharmacology·A C SimonA Benetos
Sep 1, 1983·Journal of Cardiovascular Pharmacology·P W de LeeuwW H Birkenhäger
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·H GavrasR O Davies
Sep 1, 1982·British Journal of Clinical Pharmacology·E H UlmJ L Schelling
Apr 21, 1982·The American Journal of Cardiology·G ManciaA Zanchetti
Dec 1, 1980·British Journal of Clinical Pharmacology·D CasellasC Chevillard
Feb 1, 1981·The Tohoku Journal of Experimental Medicine·Y ImaiK Yoshinaga
Aug 1, 1980·Circulation Research·D L Eckberg

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Citations

Jan 1, 1986·European Journal of Clinical Pharmacology·B P McGrath, L F Arnolda
Jan 1, 1987·European Journal of Clinical Pharmacology·A BerdeauxJ F Giudicelli
Feb 1, 1990·Cardiovascular Drugs and Therapy·N Sharpe
Jan 1, 1987·Cardiovascular Drugs and Therapy·I L Natoff
Nov 17, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kashif HanifRituraj Konwar
Dec 1, 1993·British Journal of Clinical Pharmacology·A D BainbridgeH L Elliott
Jan 1, 1989·Fundamental & Clinical Pharmacology·A Berdeaux
Jan 1, 1990·Fundamental & Clinical Pharmacology·J L GérardJ F Giudicelli
Sep 1, 1993·British Journal of Pharmacology·M Rechtman, H Majewski
Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·R G AsmarM E Safar
Aug 3, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Berend Mets
Oct 1, 1986·British Journal of Clinical Pharmacology·R H BeckerM J Brown
Jan 1, 1987·Fundamental & Clinical Pharmacology·A Berdeaux, J F Giudicelli
Mar 1, 1986·British Journal of Clinical Pharmacology·A A Ajayi, J L Reid
Mar 1, 1994·Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society·R G AnderssonK Persson
Apr 24, 1987·The American Journal of Cardiology·P U Witte, U Walter
Aug 1, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yiran Zhang, Liang Ma
Sep 2, 2009·Journal of Cardiovascular Pharmacology and Therapeutics·Mehran ShahzamaniPeyman Nejatbakhsh Azadani
Sep 6, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Casey A MuellerDane A Crossley
May 1, 1990·Journal of Neurosurgery·K L Holloway, A M Alberico
Jan 1, 1990·Postgraduate Medicine·P AmadioD M Cummings
Jan 1, 1988·Acta Medica Scandinavica·J AhlnerJ Ohlsson
May 1, 1990·DICP : the Annals of Pharmacotherapy·J J RaiaC R Lacy
Dec 23, 1998·British Journal of Clinical Pharmacology·K M Yee, A D Struthers
Dec 1, 1997·Journal of Anesthesia·Kei KohnoYoshihiro Kosaka
Mar 1, 1986·British Journal of Clinical Pharmacology·J F Giudicelli, A Berdeaux
May 13, 1998·Circulation·N J Brown, D E Vaughan
Dec 8, 1988·The New England Journal of Medicine·G H Williams

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