The effect of enalapril on furosemide-activated renin-angiotensin-aldosterone system in healthy dogs

Journal of Veterinary Pharmacology and Therapeutics
Andrea C LantisC E Atkins

Abstract

Studies in our laboratory have revealed that furosemide-induced RAAS activation, evaluated via the urine aldosterone-to-creatinine ratio (UAldo:C), was not attenuated by the coadministration of benazepril, while enalapril successfully suppressed amlodipine-induced urinary aldosterone excretion. This study was designed to evaluate the efficacy of enalapril in suppressing ACE activity and furosemide-induced circulating RAAS activation. Failure to do so would suggest that this failure may be a drug class effect. We hypothesized that enalapril would suppress ACE activity and furosemide-induced circulating RAAS activation. Sixteen healthy hound dogs. The effect of furosemide (2 mg/kg PO, q12 h; Group F) and furosemide plus enalapril (0.5 mg/kg PO, q12 h; Group FE) on circulating RAAS was determined by plasma ACE activity, 4-6 h post-treatment, and urinary A:C on days -1, -2, 1, 4, and 7. There was a significant increase in the average urine aldosterone-to-creatinine ratio (UAldo:C) after administration of furosemide (P < 0.05). Enalapril inhibited ACE activity (P < 0.0001) but did not significantly reduce aldosterone excretion. A significant (P < 0.05) increase in the UAldo:C was maintained for the 7 days of the study in both groups...Continue Reading

References

Dec 1, 1981·The Journal of Endocrinology·J StaessenA Amery
Apr 30, 1998·Journal of Veterinary Internal Medicine·R L Hamlin, T Nakayama
Aug 25, 2007·Nature Clinical Practice. Nephrology·Andrew S Bomback, Philip J Klemmer
Sep 7, 2007·Journal of Veterinary Pharmacology and Therapeutics·C E AtkinsJ F Levine
May 1, 1999·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·UNKNOWN BENCH (BENazepril in Canine Heart disease) Study Group
Nov 1, 2004·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Chris AmbergerUNKNOWN FIRST (First Imidapril Randomized Study) group
Sep 17, 2014·Journal of Veterinary Pharmacology and Therapeutics·A C LantisS R Werre

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Citations

Feb 27, 2019·Journal of Veterinary Internal Medicine·Marisa K AmesBertram Pitt
Jun 16, 2016·Journal of Veterinary Pharmacology and Therapeutics·A PanteriJ N King

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