The effect of enamel matrix derivative (Emdogain) on bone formation: a systematic review

Tissue Engineering. Part B, Reviews
Florian RatheJohn A Jansen

Abstract

This systematic review focused on the question, if and to what extent enamel matrix derivative (Emdogain) [EMD]) promotes the regeneration of bone. The influence of combinations with other biomaterials was additionally evaluated. Twenty histomorphometric studies were included in this systematic review. Main results of the reviewed articles were (i) guide tissue regeneration (GTR) of infrabony defects seems to result in a higher degree of bone regeneration compared to treatment with EMD; (ii) combined therapy (GTR + EMD) of infrabony defects might not lead to better results than GTR therapy alone; (iii) there seems to be no additional benefit of combined therapy (GTR + EMD) in furcation defects over GTR therapy alone; (iv) EMD seems to lead to more bone regeneration of infrabony defects compared to open flap debridement; (v) however, EMD application might result in more bone formation when applied in supporting defects compared to nonsupporting defects; and (vi) EMD does not seem to promote external jaw/parietal bone formation in the titanium capsule model. The results of one study that suggest that EMD increases the initial growth of trabecular bone around endosseous implants by new bone induction need to be confirmed by additi...Continue Reading

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Citations

Oct 29, 2009·Tissue Engineering. Part B, Reviews·Fa-Ming Chen, Yan Jin
Apr 19, 2012·Journal of Periodontology·Satheesh ElangovanVeerasathpurush Allareddy
Jul 15, 2015·Experimental and Therapeutic Medicine·Marzena Wyganowska-ŚwiątkowskaJerzy Jankun
Jul 27, 2011·Journal of Endodontics·Cristiano FabianiMassimo M Gagliani
Feb 22, 2012·European Journal of Oral Sciences·Maria V Obregon-WhittleJanne E Reseland
Aug 7, 2012·Journal of Periodontal Research·V T MuellerH-L Wang
Jan 5, 2011·Journal of Cellular and Molecular Medicine·Javier CatónThimios A Mitsiadis
Aug 25, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Carolin GötzAndreas Kolk
Nov 10, 2012·Journal of Prosthodontic Research·Hiroshi EgusaKentaro Akiyama
May 18, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Marco C BottinoGregg M Janowski
Jul 13, 2016·Journal of Tissue Engineering and Regenerative Medicine·Fen LiuFa-Ming Chen
May 12, 2018·International Journal of Oral Science·Sema S HakkiWerner Götz
Apr 10, 2020·The Journal of Clinical Pediatric Dentistry·Ok Hyung NamHyun-Chang Lim

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