PMID: 14417081Jun 1, 1960Paper

The effect of enzyme inhibitors on histamine catabolism in man

British Journal of Pharmacology and Chemotherapy
S E LindellH WESTLING

Abstract

The catabolism of histamine was studied in three female psychiatric patients by analysis of the [(14)C]-labelled metabolic products occurring in the urine after a subcutaneous injection of [(14)C]histamine. Each patient was studied before and during treatment with aminoguanidine or iproniazid.Without treatment the patients had a normal histamine catabolism. Aminoguanidine and iproniazid inhibited the oxidation of histamine to imidazoleacetic acid; iproniazid produed a 50% inhibition of the oxidation of methylhistamine to methylimidazoleacetic acid. After iproniazid a large proportion of the injected [C(14)]histamine was excreted as methyl [(14)C]histamine.

References

May 1, 1954·A.M.A. Archives of Neurology and Psychiatry·J D LUCY
Nov 1, 1956·Journal of Applied Physiology·J A COOPER, R W SCHAYER
Mar 7, 1957·Acta Physiologica Scandinavica·K M LINDAHLT WHITE
Jul 1, 1957·Acta Physiologica Scandinavica·S E LINDELL, H WESTLING
Oct 1, 1958·Biochimica Et Biophysica Acta·Z ROTHSCHILD, R W SCHAYER
Jan 1, 1959·Physiological Reviews·R W SCHAYER
Mar 3, 1959·The Journal of Physiology·H BLASCHKOK NILSSON
Sep 17, 1959·Annals of the New York Academy of Sciences·A SJOERDSMAS UDENFRIEND
Sep 17, 1959·Annals of the New York Academy of Sciences·O RESNICK

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Citations

Feb 1, 1971·Comparative Biochemistry and Physiology. A, Comparative Physiology·B Holstein
Jan 1, 1996·Journal of Diabetes and Its Complications·D DvornikM D Basso
Apr 1, 1961·British Journal of Pharmacology and Chemotherapy·B Lilja, S E Lindell
Jun 1, 1964·British Journal of Pharmacology and Chemotherapy·B O AMURE, M GINSBURG
Sep 1, 1967·Acta Physiologica Scandinavica·O V Sjaastad
Mar 1, 1971·Acta Physiologica Scandinavica·K A Eliassen
May 1, 1973·Acta Physiologica Scandinavica·K A Eliassen
Oct 1, 1972·British Journal of Pharmacology·B BergT White

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