The effect of ephedrine and phenylephrine on BIS values during propofol anaesthesia

European Journal of Anaesthesiology
D TakizawaH Hiraoka

Abstract

The purpose of this study was to evaluate the effect of ephedrine and phenylephrine on propofol concentrations and bispectral index during propofol anesthesia. General anaesthesia was induced with propofol and was maintained with propofol (4 mg kg-1 h-1) and fentanyl. Vecuronium was used to facilitate the artificial ventilation of the lungs. Patients with systolic blood pressure > 90 mmHg were defined as the control group (n = 16). Patients who had to be treated for larger decreases in arterial blood pressure (systolic blood pressure 60, whereas no patient in the control or phenylephrine groups had bispectral index >60. There were no significant differences in propofol concentrations or cardiac output relative to baseline at 3 or 10 min after the administration of ephedrine or phenylephrine. Ephedrine increases bispectral index values without decreasing propofol concentrations during general anesthesia.

References

May 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·J F BowyerJ Tor-Agbidye
Nov 2, 2002·Anesthesiology·Tomiei KazamaShigehito Sato
Feb 1, 2005·Anesthesiology·Daisuke TakizawaRyuya Horiuchi
Apr 27, 2005·Anesthesiology·Daisuke TakizawaFumio Goto
May 6, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Daisuke TakizawaFumio Goto
Jul 9, 2005·Clinical Pharmacology and Therapeutics·Daisuke TakizawaFumio Goto

❮ Previous
Next ❯

Citations

Oct 31, 2012·Journal of Clinical Monitoring and Computing·Hyun Jeong KwakJong Yeop Kim
Feb 21, 2013·Regional Anesthesia and Pain Medicine·Joseph Keaveney, Seosamh Ó Riain
Dec 18, 2013·Journal of Clinical Monitoring and Computing·Ji Young KimHyun Jeong Kwak
Sep 22, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Michael WeissTobias Bednarek
May 19, 2012·Journal of Medical Primatology·L HessK Stein
May 27, 2017·British Journal of Clinical Pharmacology·Tatsunori WatanabeHiroshi Baba
Jan 5, 2007·European Journal of Anaesthesiology·R A McCahonJ G Hardman
Sep 26, 2019·Scientific Reports·Hyung-Chul LeeChul-Woo Jung
May 10, 2012·European Journal of Anaesthesiology·Mehmet A ErdoganMehmet O Ersoy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.