PMID: 4890860Jun 1, 1969Paper

The effect of epithelial remnant and whole organ grafts of thymus on the recovery of thymectomized irradiated mice

The Journal of Experimental Medicine
E F Hays

Abstract

Work has been presented which suggests that thymus epithelial reticular cells are not effective in restoring the microscopic morphology of lymphoid tissues and their immunologic capacities. They function in recruiting precursors of thymus lymphocytes from the host animals to produce an organ which, after it becomes architecturally normal, can reconstitute the defective host. Intact thymus grafts in situ from 10-14 days, but not for shorter periods of time, have been shown to result in a return toward normal of these two parameters. Evidence is offered to show that few dividing cellular components in the lymphoid tissue originate from the thymus remnant grafts, and that a minor cellular component is contributed by the intact grafts. These data support the concept that the structural and functional development of the lymphatic tissue in thymectomized animals is dependent on thymus lymphoid cells and/or their products, and that the epithelial-reticular cells do not have a direct action in peripheral lymphoid reconstitution.

References

Jul 19, 1966·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·H S MicklemJ Gray
Feb 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·D Osoba
Dec 1, 1968·The Journal of Experimental Medicine·A C Aisenberg, C Davis
Mar 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·L W Law, H D Agnew
Jul 1, 1966·Transplantation·A J DaviesP C Koller
Aug 1, 1967·The Journal of Experimental Medicine·I L Weissman
Sep 19, 1964·Nature·A M CROSSE LEUCHARS

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Citations

Nov 1, 1969·Agents and Actions·A J Davies
Aug 5, 1971·The New England Journal of Medicine·C G CraddockR McMillan
Feb 28, 1975·Annals of the New York Academy of Sciences·G H CohenA L Goldstein
May 1, 1978·Seminars in Arthritis and Rheumatism·D L Robbins, M E Gershwin
Mar 1, 1984·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·S TubolyM Bucsek
Apr 1, 1979·European Journal of Immunology·K W Pyke, J F Bach

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