The effect of Epstein-Barr virus status on clinical outcome in Hodgkin's lymphoma

Annals of Hematology
J M KwonWon Seog Kim

Abstract

The association of Epstein-Barr virus (EBV) with Hodgkin's lymphoma (HL) has been investigated over the last few years. The impact of EBV on clinical outcome is still controversial, however. In this study, we investigated the effect of EBV status on clinical outcome of HL patients. Between January 1986 and September 2004, fifty-six patients, diagnosed as having HL, were included in the analysis. Clinical data were reviewed retrospectively from the patients' records. Tissues from 56 patients were analyzed for the presence of EBV using the in situ hybridization (ISH) for EBV-encoded RNA (EBER) and immunohistochemistry for latent membrane protein (LMP)1. EBV infection was identified in 41.1% of cases by EBER ISH, 26.8% by LMP1 expression, and 26.8% by LMP1 and EBER ISH. EBER-positive HL were significantly more frequent in mixed cellularity (MC) subtype (P=0.014) and advanced stage (P=0.034). There was a trend toward shorter overall survival in EBER-positive patients without statistical significance (P=0.238). LMP1 expression also correlated with MC subtype (P=0.006) and advanced stage (P=0.007), although it did not significantly influence the survival outcome. In subgroup analysis, both EBER and LMP1 positivities were associated w...Continue Reading

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Citations

Nov 21, 2007·Hematology·Richard F Ambinder
Feb 2, 2011·Haematologica·Christian SteidlRandy D Gascoyne
Jan 1, 2009·Mediterranean Journal of Hematology and Infectious Diseases·Giuseppina MassiniStefan Hohaus
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Jul 22, 2014·British Journal of Haematology·Olivier MoralesNadira Delhem
Dec 5, 2015·Iranian Journal of Pediatrics·Hikmet Gulsah TanyildizHilmi Apak
Feb 20, 2008·Leukemia Research·Semra PaydasGulsah Seydaoglu
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arjan DiepstraSibrand Poppema
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian SteidlRandy D Gascoyne
Dec 31, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Ben Dhiab MyriamTrimeche Mounir
Nov 23, 2017·Laboratory Medicine·Sujal ShahRandall Butler
Mar 28, 2013·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Kaja RahuMati Rahu
Jul 14, 2020·Scottish Medical Journal·Nives JonjićKoviljka Matušan Ilijaš
Jan 24, 2015·Experimental & Molecular Medicine·Young-Hyeh Ko

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