The effect of essential fatty acid deficiency on the fatty acid composition of different salivary glands and saliva in rats

Archives of Oral Biology
S Q Alam, Y Y Shi

Abstract

The main purpose was to compare the changes in fatty acid composition of lipids induced by essential fatty acid (EFA) deficiency in the rat submandibular, parotid and sublingual glands. Three groups of rats were fed for 28 weeks (1 week gestation, 3 weeks lactation and 24 weeks thereafter) diets containing 7% hydrogenated coconut oil (HCO) (EFA-deficient in both n-6 and n-3), 7% soybean oil (SBO) (control) and 7% safflower oil (SFO) (deficient in n-3). Rats were killed and salivary glands were dissected out. Lipids were extracted and the fatty acid composition of total lipids and phospholipids was determined by gas chromatography-mass spectrometry. The fatty-acid compositional changes indicative of an EFA deficiency, such as decreases in the levels of 18:2 n-6, along with an accumulation of 20:3 n-9, were generally observed in all the salivary glands of rats fed 7% HCO diet. In the submandibular glands, the proportions of 16:1, 18:1 n-9 and 18:1 n-7 were also higher in the HCO-fed group than in the other two groups. There were some differences in the fatty acid composition of the three glands. Total lipids of parotid gland had higher levels of 12:0 and 18:1 n-9 as compared to the other two glands. The levels of 18:0, 20:3 n-9, ...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·J BannetR H Belmaker
Jul 1, 1975·Archives of Oral Biology·J L Rabinowitz, I L Shannon
Apr 1, 1976·Biomedical Mass Spectrometry·M E WardS Q Alam
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R T HolmanP L Ogburn
Jun 14, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·M A McPhersonM C Goodchild
Jan 1, 1986·Archives of Oral Biology·B L SlomianyI D Mandel
Jan 9, 1985·Biochimica Et Biophysica Acta·S Q Alam, B S Alam
Dec 18, 1972·Annals of the New York Academy of Sciences·B A UnderwoodM Navab
Feb 1, 1969·Archives of Oral Biology·I D Mandel, A Eisenstein
Dec 1, 1970·Archives of Oral Biology·A BlochR M Frank
May 1, 1982·The Journal of Nutrition·A Q Alam, B S Alam
Mar 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S M Abdel-HakimS Q Alam
Jan 1, 1996·Archives of Oral Biology·B LarssonT Ericson
Dec 1, 1996·The Journal of Nutrition·M MoussaJ P Thouvenot
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Dec 1, 1945·Journal of Dental Research·F KRASNOW

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Citations

Sep 28, 2007·Journal of Oleo Science·Yumiko TomitaSumie Yamanaka
Apr 25, 2007·European Journal of Oral Sciences·Christine DelporteYvon A Carpentier
Dec 16, 2004·Archives of Oral Biology·Adriana B ActisAldo R Eynard

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