The effect of ethanol, beer, and wine on histamine release from the dog stomach

Alcohol
L IntorreG Soldani

Abstract

The mediator for the action of ethanol on the parietal cell of the stomach is not known. However, because the action of ethanol on gastric acid secretion was proposed to involve the release of histamine, we decided to investigate the effects of ethanol and some alcoholic beverages (red wine and beer) on histamine release from the dog stomach. After performing a splenectomy in anaesthetized beagle dogs, the gastrosplenic vein draining the corpus of the stomach was cannulated for blood withdrawal to evaluate the local release of gastrin and histamine by RIA. Intragastric administration of 200 ml of beer (4.8% ethanol) or red wine (12.5% ethanol) caused a significant enhancement in gastrin and histamine concentrations in venous blood from the stomach. By contrast, intragastric administration of pure ethanol in distilled water at the same concentrations of wine or beer did not significantly modify gastrin and histamine release. Integrated histamine responses for 20 min to beer and wine paralleled gastrin concentrations and were of the same magnitude of those induced by intravenous infusion of pentagastrin at 1 and 6 micrograms/ kg/h, respectively. We conclude that: 1) beer and red wine, but not pure ethanol, are potent releasers of...Continue Reading

References

Jan 1, 1991·Scandinavian Journal of Gastroenterology. Supplement·A K Sandvik, H L Waldum
Jul 29, 1972·British Medical Journal·E R Trethewie, L Khaled
Dec 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·H W Davenport
Jan 1, 1984·Digestive Diseases and Sciences·V E EysseleinH Goebell
Aug 1, 1993·Gastroenterology·C PrinzG Sachs
Aug 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J G Gerber, N A Payne
Jul 1, 1996·Scandinavian Journal of Gastroenterology·G SoldaniJ C Schwartz

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