The effect of ethanol on arrhythmias and myocardial necrosis in rats with coronary occlusion and reperfusion

European Journal of Pharmacology
W Bernauer

Abstract

Ethanol (1, 2 and 3 g/kg, intravenously) decreased the severity of the ischemic arrhythmias in rats with ligation of the left coronary artery and subsequent coronary reperfusion. Reperfusion arrhythmias occurring intensively after occlusion times of 5 and 15 min, respectively, were however not antagonized. Similar results were obtained in isolated perfused rat hearts with final concentrations of 4 and 6 mg ethanol/ml. In rats with reperfusion after 60 min of coronary occlusion, 2 g ethanol/kg significantly reduced the percentage of the ischemic area which underwent necrosis. Moreover, the increase in the wet weight/dry weight ratio of the lungs, as a measure of edema formation, was prevented. The ethanol effects are discussed in the light of present knowledge of the pathogenesis of arrhythmias and myocardial necrosis in experimental myocardial infarction.

References

Aug 1, 1979·Cardiovascular Research·H S FriedmanC S Lieber
May 1, 1978·American Heart Journal·P O EttingerT J Regan
Aug 1, 1977·Journal of Molecular and Cellular Cardiology·D J Hearse
Sep 1, 1976·Journal of Molecular and Cellular Cardiology·Y HirotaW H Abelmann
Jan 1, 1974·Circulation·L D Horwitz, J M Atkins
Feb 1, 1972·European Journal of Pharmacology·J Nakano, J M Kessinger
Feb 1, 1966·The Journal of Clinical Investigation·R J ReganH K Hellems
Jun 1, 1984·Journal of Molecular and Cellular Cardiology·A S Manning, D J Hearse
Oct 1, 1983·Cardiovascular Research·S PescioR J Domenech
Apr 1, 1983·Journal of the American College of Cardiology·J Schaper, W Schaper
Aug 1, 1982·Annals of Internal Medicine·B H GreenbergH Griswold
Feb 8, 1980·European Journal of Pharmacology·J TalesnikY Israel
Jan 1, 1981·The American Journal of Cardiology·H S Friedman

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Citations

May 24, 2005·Pflügers Archiv : European journal of physiology·Louis-Jean BordeleauPascal Daleau
Mar 18, 2004·Antioxidants & Redox Signaling·Andry RakotovaoFrançois Boucher
May 7, 2003·Preventive Cardiology·Kenneth J Mukamal
Oct 28, 1999·American Heart Journal·K J MukamalM A Mittleman
Jun 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L A NevesR A Santos
Jul 5, 2013·American Journal of Audiology·Sara Conrad, Ayasakanta Rout
May 30, 2008·Cognition & Emotion·Seth Duncan, Lisa Feldman Barrett
Mar 25, 2004·Physiological Genomics·Robson A S SantosMichael Bader

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