PMID: 9545590Apr 18, 1998Paper

The effect of ethanol on pancreatic enzymes--a dietary artefact?

Biochimica Et Biophysica Acta
M V ApteJ Wilson

Abstract

The effects of ethanol on pancreatic digestive and lysosomal enzymes may be relevant to the pathogenesis of alcoholic pancreatitis since pancreatic enzymes are thought to play an important role in the development of pancreatic injury. Previous studies, using the Lieber-DeCarli pair-feeding model of ethanol administration, have demonstrated that ethanol significantly increases the content and gene expression of pancreatic enzymes. However, these findings have been questioned because, in the Lieber-DeCarli model, ethanol-fed rats have a lower carbohydrate intake than their pair-fed controls, making it difficult to ascribe any observed changes to ethanol alone. This study was designed to distinguish between the effects of ethanol and those of reduced dietary carbohydrate on pancreatic enzymes, using a quartet-feeding model of ethanol administration. Rats were fed liquid diets containing low (11%) and high (47%) amounts of carbohydrate, with and without ethanol, for four weeks. The effects of ethanol on pancreatic content and messenger RNA levels for digestive enzymes (trypsinogen, chymotrypsinogen and lipase) and a lysosomal enzyme (cathepsin B) were assessed. Ethanol feeding resulted in a significant increase in glandular content...Continue Reading

References

Nov 1, 1977·Analytical Biochemistry·J Kapuściński, B Skoczylas
Jan 1, 1976·The American Journal of Clinical Nutrition·R C Pirola, C S Lieber
Dec 1, 1975·The Journal of Nutrition·R C Pirola, C S Lieber
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·G Klöppel, B Maillet
Jun 1, 1990·Digestive Diseases and Sciences·H OnoH Sobajima
Jan 1, 1989·Pancreas·H YamaguchiH Nawata
Oct 1, 1986·Alcoholism, Clinical and Experimental Research·C S Lieber, L M DeCarli
Sep 8, 1988·Biochimica Et Biophysica Acta·B C PonnappaE Rubin
Jan 1, 1974·Nutrition and Metabolism·M J Stock, J A Stuart
Jul 1, 1995·The American Journal of Clinical Nutrition·T J HortonJ O Hill
Feb 1, 1995·Current Opinion in Lipidology·L Lissner, B L Heitmann
Apr 1, 1994·Gut·R W Ammann, B Muellhaupt
May 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·L M GREENBAUM, A HIRSHKOWITZ
Jun 1, 1965·The Journal of Clinical Investigation·C S LIEBERL M DECARLI
Dec 1, 1959·Canadian Journal of Biochemistry and Physiology·B C HUMMEL

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Citations

Feb 24, 2001·Journal of Physiology and Biochemistry·J J AcostaJ J Calvo
Feb 17, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·D M Goldberg
Jun 28, 2003·Best Practice & Research. Clinical Gastroenterology·Sören SiegmundManfred V Singer
Jul 26, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Alexander SchneiderManfred V Singer
Nov 6, 2004·Gastroenterology Clinics of North America·Nevin Oruc, David C Whitcomb
Oct 25, 2003·Pancreas·Ashok K Saluja, Lakshmi Bhagat
Apr 20, 2004·The American Journal of Gastroenterology·Cynthia MortonNatalia Udaltsova
Mar 2, 2006·Digestive Diseases·Soren V SiegmundManfred V Singer
Mar 3, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anna OrekhovaMiklós Sahin-Tóth
May 21, 2020·The American Journal of Chinese Medicine·Ji-Won ChoiSung-Joo Park
Apr 3, 2008·Cancer Research·Alain VonlaufenMinoti V Apte
Jan 6, 2005·The American Journal of Pathology·Xiaoying DengDavid C Whitcomb

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