PMID: 1212195Sep 1, 1975Paper

The effect of ethionine on ribonucleic acid synthesis in rat liver

The Biochemical Journal
P F Swann

Abstract

1. By 1h after administration of ethionine to the female rat the appearance of newly synthesized 18SrRNA in the cytoplasm is completely inhibited. This is not caused by inhibition of RNA synthesis, for the synthesis of the large ribosomal precursor RNA (45S) and of tRNA continues. Cleavage of 45S RNA to 32S RNA also occurs, but there was no evidence for the accumulation of mature or immature rRNA in the nucleus. 2. The effect of ethionine on the maturation of rRNA was not mimicked by an inhibitor of protein synthesis (cycloheximide) or an inhibitor of polyamine synthesis [methylglyoxal bis(guanylhydrazone)]. 3. Unlike the ethionine-induced inhibition of protein synthesis, this effect was not prevented by concurrent administration of inosine. A similar effect could be induced in HeLa cells by incubation for 1h in a medium lacking methionine. The ATP concentration in these cells was normal. From these two observations it was concluded that the effect of etionine on rRNA maturation is not caused by an ethionine-induced lack of ATP. It is suggested that ethionine, by lowering the hepatic concentration of S-adenosylmethionine, prevents methylation of the ribosomal precursor. The methylation is essential for the correct maturation of...Continue Reading

Citations

Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·K T TycowskiJ A Steitz
May 15, 1979·European Journal of Biochemistry·B B Stoyanova, A A Hadjiolov
Jan 11, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·G K Grimble
May 24, 2020·Biomolecules·Sandeep OjhaShawn M Lyons
Jan 1, 1976·Progress in Biophysics and Molecular Biology·A A Hadjiolov, N Nikolaev
Jan 1, 1997·Molecular and Cellular Biology·B HongJ P Aris
Oct 3, 1977·Advances in Enzyme Regulation·O K SharmaE Borek
Dec 1, 1976·Biochimica Et Biophysica Acta·R F ItzhakiR W Billington
Aug 1, 1986·Biochemical Medicine and Metabolic Biology·K SchottV Neuhoff
Oct 15, 1995·Genes & Development·D LafontaineD Tollervey

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