The effect of Euryale ferox (Makhana), an herb of aquatic origin, on myocardial ischemic reperfusion injury.

Molecular and Cellular Biochemistry
Samarjit DasD K Das

Abstract

Fox nut or gorgon nut (Euryale ferox--Family Nymphaeaceae), popularly known as Makhana, has been widely used in traditional oriental medicine to cure a variety of diseases including kidney problems, chronic diarrhea, excessive leucorrhea and hypofunction of the spleen. Based on the recent studies revealing antioxidant activities of Euryale ferox and its glucosides composition, we sought to determine if Euryale ferox seeds (Makhana) could reduce myocardial ischemic reperfusion injury. Two different models were used: acute model, where isolated rat hearts were preperfused for 15 min with Krebs Henseleit bicarbonate (KHB) buffer containing three different doses of makhana (25, 125 or 250 microg/ml) followed by 30 min of ischemia and 2 h of reperfusion; and chronic model, where rats were given two different doses of makhana (250 and 500 mg/kg/day) for 21 days, after which isolated hearts were subjected to 30 min of ischemia followed by 2 h of reperfusion. In both cases, the hearts of the Makhana treated rats were resistant to ischemic reperfusion injury as evidenced by their improved post-ischemic ventricular function and reduced myocardial infarct size. Antibody array technique was used to identify the cardioprotective proteins. T...Continue Reading

References

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Dec 30, 2004·Journal of Molecular and Cellular Cardiology·Praveer MathurNilanjana Maulik

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Citations

Jul 22, 2010·Pharmaceutical Biology·Rahila AhmadUma Bhandari
Nov 30, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Qing LiuDaping Fan
Jan 1, 2009·Molecular Ecology Resources·Zhiwu QuanYi Ding
Jun 15, 2012·Journal of Asian Natural Products Research·Zhi HanLing-Yi Kong
Dec 19, 2020·Toxicon : Official Journal of the International Society on Toxinology·Zong-Yao QianQi-Ming Xian
Feb 2, 2011·Journal of Agricultural and Food Chemistry·Chang-Wei SongYong-Xian Cheng

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