The effect of excess weight on circulating inflammatory cytokines in drug-naïve first-episode psychosis individuals

Journal of Neuroinflammation
María Juncal-RuizBenedicto Crespo-Facorro

Abstract

Low-grade inflammation has been repeatedly associated with both excess weight and psychosis. However, no previous studies have addressed the direct effect of body mass index (BMI) on basal serum cytokines in individuals with first-episode psychosis (FEP). The aim of this study is to analyze the effect of BMI on basal serum cytokine levels in FEP patients and control subjects, separating the total sample into two groups: normal-weight and overweight individuals. This is a prospective and open-label study. We selected 75 FEP patients and 75 healthy controls with similar characteristics to patients according to the following variables: sex, age, and cannabis and tobacco consumption. Both controls and patients were separated into two groups according to their BMI: subjects with a BMI under 25 were considered as normal weight and those with a BMI equal to or more than 25 were considered as overweight. Serum levels of 21 cytokines/chemokines were measured at baseline using the Human High Sensitivity T Cell Magnetic Bead Panel protocol from the Milliplex® Map Kit. We compared the basal serum levels of the 21 cytokines between control and patient groups according to their BMI. In the normal-weight group, IL-8 was the only cytokine that...Continue Reading

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Citations

Aug 29, 2020·International Journal of Molecular Sciences·Maria Juncal-RuizBenedicto Crespo-Facorro
Mar 8, 2019·European Child & Adolescent Psychiatry·C MorenoUNKNOWN From the FLAMM-PEPs study, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
Apr 12, 2019·NPJ Schizophrenia·Benedicto Crespo-FacorroJesus Sainz
Jan 2, 2021·Journal of Psychiatric Research·Guillermo Pardo-de-SantayanaBenedicto Crespo-Facorro
Jun 3, 2021·International Journal of Environmental Research and Public Health·Roxana Maria Martin-HadmașCristina Oana Mărginean

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