The effect of exogenous surfactant therapy on lung function following cardiopulmonary bypass

Chest
P D Macnaughton, T W Evans

Abstract

Pilot study to investigate the effect of exogenous surfactant therapy on lung function following cardiopulmonary bypass (CPB). Prospective randomized controlled study. Adult intensive care unit of a postgraduate cardiothoracic hospital. Sixteen adult patients undergoing elective coronary artery revascularization surgery without a history of preoperative respiratory disease. Artificial lung-expanding compound (ALEC, Britannia Pharmaceuticals, Crawley, UK) 3.2 g, was given via a bronchoscope 60 min after bypass in eight patients. Eight control subjects received air. Lung function tests during IPPV (arterial blood gas tensions, Crs, FRC, TLco, KCO) were measured prior to CPB, before therapy, and at regular intervals up to 180 min afterwards. The CPB caused a significant impairment of lung function in both groups with an increase in A-a gradient (+47 +/- 11 mm Hg in the ALEC group and +44 +/- 17 mm Hg in controls) and reductions in FRC (-290 +/- 121 ml in the ALEC group and -470 +/- 132 ml in controls), TLco (-1.6 +/- 0.3 ml/min/mm Hg in the ALEC group and -2.2 +/- 0.3 ml/min/mm Hg in controls), and Crs (-10 +/- 1 ml/cm H2O in the ALEC group and -21 +/- 4 ml/cm H2O in controls). The ALEC therapy did not affect A-a gradient, FRC, an...Continue Reading

References

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Citations

May 28, 2005·The Annals of Thoracic Surgery·Shuichi ShiraishiSoichiro Kitamura
Mar 29, 2000·The Annals of Thoracic Surgery·T SuzukiI Kashima
Aug 10, 1999·Journal of the American College of Cardiology·L D ThompsonF L Hanley
Feb 17, 2000·Journal of the American College of Cardiology·W TworetzkyJ R Fineman
Jan 19, 1999·Critical Care Clinics·T E Albertson, G P Marelich
May 18, 1999·Archives of Disease in Childhood·J López-HerceR Moral
Apr 12, 2002·Chest·Calvin S H NgAhmed A Arifi
Nov 26, 2010·Congenital Heart Disease·Jeffrey A AltenJames K Kirklin
Sep 15, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Shahzad G Raja, Gilles D Dreyfus
Jul 29, 1999·The Journal of Thoracic and Cardiovascular Surgery·M GrieseC Rinker

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