PMID: 2113760May 1, 1990Paper

The effect of external stimuli on rat middle ear epithelium in culture. Extracellular carbon dioxide concentration

Acta Oto-laryngologica
H W LutgertJ J Grote

Abstract

Serially cultivated rat middle ear epithelium was studied under exposure to various concentrations of carbon dioxide. Three experiments were performed exposing the epithelium to a gaseous environment containing 5 or 10% CO2 or to an atmosphere almost devoid of CO2. Oxygen was maintained constant at 20% and nitrogen was additionally supplied. Cells exposed at 0% CO2 showed a remarkably different morphology compared with the cultures at 5 and 10% CO2, cells could become extremely large at 0% CO2, also showing a great variation in shape and cell size within the culture. Proliferation was significantly impaired at 0% CO2 vis-à-vis the 5 and 10% experiments. Terminal differentiation, however, was not influenced by the different CO2 concentrations, indicating that in vitro, variation in CO2 concentration is of no importance regarding a possible differentiation of middle ear epithelium into a cornifying epithelium.

References

Mar 1, 1975·The Annals of Otology, Rhinology, and Laryngology·S IngelstedtH Rundcrantz
Mar 1, 1976·The Annals of Otology, Rhinology, and Laryngology·E I Cantekin, C D Bluestone
May 1, 1986·Acta Oto-laryngologica·C A van BlitterswijkJ J Grote
May 1, 1973·The Annals of Otology, Rhinology, and Laryngology·S D GreenbergJ G Neely
Jan 1, 1970·Cancer·O AuerbachL Garfinkel
Dec 1, 1983·The Journal of Laryngology and Otology·G D Smyth, S Hall
Jan 1, 1980·Acta Oto-laryngologica·E OstfeldA Szeinberg
May 1, 1980·The Annals of Otology, Rhinology & Laryngology. Supplement·C Morgenstern
Feb 1, 1955·A.M.A. Archives of Otolaryngology·H MATSUMURA
Mar 26, 1956·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·H B FELL

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