The effect of fentanyl on electrophysiologic recovery of CA 1 pyramidal cells from anoxia in the rat hippocampal slice

Anesthesia and Analgesia
J CharchafliehI S Kass

Abstract

Fentanyl is widely used in conditions in which the brain is at risk of ischemic or anoxic injury. We evaluated the effect of fentanyl on anoxic injury to CA 1 pyramidal cells in the rat hippocampus. These neurons are extremely sensitive to anoxic injury and are densely populated with opioid receptors. We prepared hippocampal slices from adult Sprague-Dawley rats and evoked a postsynaptic population spike in the CA 1 pyramidal cell region by stimulating the Schaffer collateral pathway. The amplitude of this response was used to evaluate the effect of fentanyl on anoxic injury. Pretreatment with fentanyl (50 or 500 ng/mL) did not alter the amplitude of the CA 1 population spike before anoxia, nor did it alter the recovery of this response after 5,6, or 7 min of anoxia. After 5 min of anoxia, the population spike recovered to 76% of its preanoxic level in the control group and to 87% in the group treated with 500 ng/mL of fentanyl. After 6 min of anoxia, recovery was 45% in the control group, 57% in the group treated with 50 ng/mL of fentanyl, and 58% in the group treated with 500 ng/mL of fentanyl. After 7 min of anoxia, recovery was 5% in the control group and 4% in the group treated with 50 ng/mL of fentanyl. We conclude that f...Continue Reading

References

Feb 1, 1978·Clinical Pharmacology and Therapeutics·R SchleimerG Henderson
Feb 1, 1991·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·T TamuraI Waki
Jun 1, 1990·Stroke; a Journal of Cerebral Circulation·C ScaviniG Racagni
Jul 1, 1987·Stroke; a Journal of Cerebral Circulation·R L Fried, T S Nowak
Feb 1, 1987·Anaesthesia·B L LoughnanH Rogers
Sep 1, 1984·Anesthesiology·S K SamraM M Kirsh
Feb 1, 1984·Anesthesia and Analgesia·J E WynandsD G Whalley
Feb 17, 1995·Neuroscience Letters·B PrzewłockaR Przewłocki
Dec 15, 1994·Biochemical and Biophysical Research Communications·S R GeorgeB F O'Dowd
Dec 15, 1994·The Journal of Comparative Neurology·A MansourS J Watson
Oct 27, 1997·Journal of Neurosurgical Anesthesiology·Y MorimotoD S Warner

❮ Previous
Next ❯

Citations

Jul 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K S HendrichC Ho
Oct 16, 2007·Brain Research·Susanne Ammon-TreiberVolker Höllt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.