The effect of fiber length on the dissolution by macrophages of rockwool and glasswool fibers

Environmental Research
K LuotoK Savolainen

Abstract

The effect of fiber length on the dissolution of experimental rockwool and commercial glasswood fibers in rat alveolar macrophage (AM) culture and in mere culture medium was studied. The ultrastructure of macrophages after their exposure to fibers and the suitability of macrophage-type cell line P388D1 culture in dissolution studies were also explored. The fiber samples included short (ground) and long (untreated) rockwool and glasswool fibers. The fibers were incubated in rat AM cultures, in P388D1 culture, or in mere culture medium for 4 or 8 days. The dissolution of the fibers was determined by measuring the amounts of silicon (Si), iron (Fe), and aluminum (Al) in the medium. There were no differences in the diameter of the fibers, but a clear difference existed in the length of the short and long fibers. The dissolution of Si, Fe, and Al was more pronounced from experimental rockwool than from commercial glasswool fibers. The dissolution of Si was always greater in mere culture medium than in rat AM culture. Moreover, the dissolution of Si was greater from the long fibers than from the short ones. On the contrary, the dissolution of Fe and Al in AM culture exceeded that in mere culture medium. The dissolution of Si, Fe, and...Continue Reading

Citations

Mar 23, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·M Dörger, F Krombach
Nov 21, 2007·Critical Reviews in Toxicology·David M Bernstein
Aug 8, 2008·Critical Reviews in Toxicology·Hermine Dika NgueaBertrand Rihn
Jul 4, 2006·Regulatory Toxicology and Pharmacology : RTP·David M Bernstein, John A Hoskins
Apr 28, 2005·Archives of Toxicology·Hermine Dika NgueaAlain Le Faou
Jul 21, 1999·Human & Experimental Toxicology·M RuotsalainenK M Savolainen
Nov 15, 2007·Archives of Toxicology·Hermine Dika NgueaBertrand H Rihn
Apr 13, 1999·Journal of Cataract and Refractive Surgery·C C Neubaur, G Stevens
Nov 5, 2019·Chemical Research in Toxicology·Susanne H Q BarlySusan L S Stipp

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.