PMID: 7170703Jan 1, 1982

The effect of fibrin on endothelial cell migration in vitro

Tissue & Cell
R R Schleef, C Birdwell


Endothelial cells are known to migrate and come into contact with fibrin during numerous physiological processes, such as in wound healing and in tumor growth. The present study was initiated to investigate the effect of fibrin on endothelial cell migration in vitro. Endothelial cell migration was assayed by wounding confluent monolayers of bovine aortic endothelial cells with a razor blade and counting the number of cells crossing the wound per unit time. Wound-induced proliferation of endothelial cells was inhibited by mitomycin C-treatment without affecting endothelial cell migration, indicating that in this assay migration could be measured independent of proliferation. Migration of endothelial cells in vitro was inhibited by fibrin in a concentration dependent manner. Endothelial cell migration under fibrin was further reduced by plasminogen depletion of the serum, and fibrin still inhibited the migration of mitomycin C-treated endothelial cells. Kadish et al. (Tissue and Cell, 11, 99, 1979) previously reported that fibrin did not affect EC migration in vitro. The inability to inhibit EC migration with fibrin appears to be due to their assay system which employed agarose, since pre-treating the wounded monolayer with agaro...Continue Reading


Aug 16, 1978·Molecular and Cellular Biochemistry·K C Robbins
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·S L SwainR W Dutton
Jan 1, 1979·Tissue & Cell·J L KadishJ Folkman
May 1, 1979·The Journal of Cell Biology·S C Selden, S M Schwartz
Aug 1, 1979·Atherosclerosis·J L Kadish
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·D GospodarowiczC Birdwell
Dec 8, 1972·Annals of the New York Academy of Sciences·K LakiJ Farrell
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R R Bürk
Mar 1, 1968·Biochemical Pharmacology·T Astrup
Jul 1, 1959·The Journal of Pathology and Bacteriology·A S TODD
Mar 5, 1962·Biochimica Et Biophysica Acta·A J SHATKINE L TATUM
Sep 1, 1963·The Journal of Experimental Medicine·P VASSALLIR T MCCLUSKEY


Nov 1, 1992·Journal of Cellular Biochemistry·B L Coomber
Jul 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·A M Schor, S L Schor
May 25, 1984·Journal of Immunological Methods·J L Obeso, R Auerbach
Jan 1, 1991·Pharmacology & Therapeutics·R Eisenstein
Sep 11, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Thao-Nguyen NguyenJ Thomas Pento
Dec 10, 2002·Journal of Vascular and Interventional Radiology : JVIR·Masao HamuroNorihumi Nishida
Jan 1, 1997·Journal of Vascular and Interventional Radiology : JVIR·E A SpragueJ C Palmaz
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·A Sahni, C W Francis
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·A SahniC W Francis
Oct 1, 1990·Analytical Biochemistry·K JozakiD L Kreutzer
Mar 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Koichi UnoTarl W Prow
Jan 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·K L KaplanS Solomon
Mar 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R I LevinE A Jaffe
May 18, 1999·The Journal of Biological Chemistry·A SahniC W Francis

Related Concepts

Blood Vessel
Bos indicus
Cell Division Phases
Cell Motility
Antithrombin I

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.