PMID: 11925463Apr 2, 2002Paper

The effect of five-year zinc supplementation on serum zinc, serum cholesterol and hematocrit in persons randomly assigned to treatment group in the age-related eye disease study: AREDS Report No. 7

The Journal of Nutrition
Age-Related Eye Disease Study Research Group

Abstract

The effects of long-term supplementation with pharmacologic doses of zinc oxide on serum levels of zinc, lipids and hematocrit have not been studied systematically to date. Eleven Clinical Centers enrolled 4757 participants from 1992 to 1998 as part of the Age-Related Eye Disease Study (AREDS). Of these, 3640 participants, aged 55-80 y, who had early-to-late age-related macular degeneration (AMD) were randomly assigned to daily supplementation with or without 80 mg of zinc as zinc oxide plus 2 mg of copper as cupric oxide to study the effects of zinc supplementation on the progression to late AMD. This paper reports on the effect of a 5-y supplementation with zinc oxide and cupric oxide on serum zinc, copper, lipids, and hematocrit for 717 participants from three clinical centers. At the 5-y exam, the median increase in serum zinc levels for participants assigned to zinc formulations was 17% compared with a 2% increase for participants not assigned to zinc (P < 0.001). The differential effect on serum zinc was observed at 1 y and remained fairly constant over the 5-y period. After 5 y, no significant differences in changes in serum hematocrit, copper or lipids were found between participants assigned to formulations containing ...Continue Reading

Associated Clinical Trials

References

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Citations

Oct 29, 2005·European Journal of Clinical Nutrition·M Andriollo-SanchezA-M Roussel
Jan 27, 2005·Clinical & Experimental Ophthalmology·Paul E Beaumont, Hyong K Kang
Sep 1, 2006·Journal of the American College of Nutrition·Suzanne Hughes, Samir Samman
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Jan 31, 2015·PloS One·Renata Markiewicz-ŻukowskaMaria H Borawska
Aug 6, 2015·Nutrition & Metabolism·Priyanga RanasingheG R Constantine
Jul 13, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Wei ChenMichal L Melamed
Nov 14, 2015·PharmacoEconomics·Jordana K Schmier, Carolyn K Hulme-Lowe
Jun 9, 2020·American Journal of Ophthalmology·Scott W McPhersonFrederik J van Kuijk
Apr 22, 2021·International Immunopharmacology·Sima Heydarzadeh AslReza Jafari
Oct 14, 2008·American Journal of Ophthalmology·Jay C ErieJose S Pulido
Sep 25, 2021·Scientific Reports·Brandon JacobsTimothy W Corson

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