PMID: 7542815Jul 27, 1995Paper

The effect of FK506 on glycemic response as assessed by the hyperglycemic clamp technique

Transplantation
P StrumphP Carroll

Abstract

We studied seven nondiabetic subjects with the autoimmune diseases psoriasis, multiple sclerosis, and primary biliary sclerosis who were to receive FK506 as experimental immunotherapy. All subjects underwent two standard oral glucose tolerance tests and two 180-min hyperglycemic clamps immediately before and 10 weeks after starting FK506. There was no significant difference in weight or HbA1c pre- vs. post-FK506 treatment. FK506 levels were therapeutic and non-toxic (0.1-1 ng/ml) for all subjects studied. Repeated measures analysis of variance for interaction between time and treatment was performed on insulin (after outlier removed) and glucose values from the OGTT. There was neither time-by-treatment interaction, nor a treatment effect (P > 0.1). There were no significant differences in pre- vs. post-FK506 treatment values of plasma glucose during the hyperglycemic clamp mean acute insulin response to glucose (AIRG) 164 +/- 38 pmol/L vs. 148 +/- 46 pmol/L (P > 0.1); mean incremental area under the insulin curve (IAUC) during the first 10 min of the study, 473 +/- 109 pmol/L vs. 443 +/- 146 pmol/L (P > 0.1); total area under the insulin curve (TAUC) during the first 10 min of the study, 786 +/- 152 pmol/L vs. 781 +/- 18 pmol/L...Continue Reading

Citations

Sep 27, 2014·Expert Opinion on Drug Metabolism & Toxicology·Erika B Rangel
Oct 13, 2011·British Journal of Clinical Pharmacology·Lara Aygen ØzbayKaj Anker Jørgensen
Sep 26, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·L A OzbayK A Jørgensen
Feb 24, 2007·Annales d'endocrinologie·M-C VantyghemC Noël
Jul 9, 2004·Transplantation·Christoph D DieterleRüdiger Landgraf

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