PMID: 7539646Jan 1, 1994Paper

The effect of FK506 on warm ischemia and reperfusion injury in the rat liver

Surgery Today
H WakabayashiT Maeba

Abstract

The protective effect of FK506 on hepatocytes against ischemia and reperfusion injury was examined by evaluating the following: the high energy phosphorus metabolism obtained using 31P magnetic resonance spectroscopy (31P-MRS) and the tissue blood flow of the liver in ischemia and the reperfusion process, mitochondrial glutamic oxaloacetic transaminase (m-GOT) and glutamic pyruvic transaminase (GPT), the survival rates of the animals, a histological study and immunohistological staining for intercellular adhesion molecule-1 (ICAM-1) in the liver after ischemia. The rats were treated with FK506 1 mg/kg/day i.m. for 4 days before testing. Ischemia was induced by clamping the hepatoduodenal ligament for 30 min. In 31P-MRS, the recovery of the hepatic energy status after ischemia, evaluated by beta-ATP/inorganic phosphate (Pi), was significantly better in the FK506 group. It also coincided with the recovery of tissue blood flow monitored with a laser Doppler flowmeter. In the histological examination, the congestion observed in the periportal region of the control group was mild, while there was less induction of ICAM-1 in the endothelial cells of the portal veins and hepatic veins in the FK506 group. From these findings, we conclu...Continue Reading

References

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Citations

Feb 6, 2004·The Journal of Thoracic and Cardiovascular Surgery·Steven M WoolleyMichael S Mulligan
Aug 26, 1998·Journal of Gastroenterology and Hepatology·F TamuraK Okita
Mar 6, 2004·The Journal of Medical Investigation : JMI·Manabu SakaiHiroshi Kido
Oct 9, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Masashi MaedaTakehiko Yanagihara
Jan 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shawn D St PeterDavid C Mulligan
Jul 11, 1998·Stroke; a Journal of Cerebral Circulation·A TsujikawaY Honda
Feb 1, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marina LaurensDominique Crenesse

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