The effect of flavonoids on visual function in patients with glaucoma or ocular hypertension: a systematic review and meta-analysis

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Shaheen PatelAndrea J Braakhuis

Abstract

Glaucoma is a leading cause of irreversible blindness worldwide. A major symptom of this pathology is the loss to the visual field in a peripheral to central pattern. Flavonoids are polyphenol compounds sourced from plants, commonly found in green tea, red wine and cocoa, and they have neuroprotective and antioxidant characteristics proposed to be advantageous within the context of glaucoma. Currently, the literature presents conflicting evidence regarding the effect of flavonoids on patients with glaucoma and ocular hypertension; hence a systematic review and meta-analysis was conducted. Databases included in our literature search were EMBASE (1980-present), MEDLINE Ovid, Alternative and Complementary Medicine Database (AMED), Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Cochrane Central Register of Controlled Trials (CENTRAL). Meta-analysis was performed using RevMan 5 (Review Manager) 5 software, version 5.3 (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen). The primary outcomes were visual field mean deviation (MD) and intraocular pressure (IOP). Secondary outcomes were ocular blood flow and blood pressure (BP). Meta-analyses showed that flavonoids have a promising role in improvi...Continue Reading

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Citations

Sep 8, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Dan Milea, Tin Aung
Mar 15, 2018·Acta Ophthalmologica·Jae H KangLouis R Pasquale
Aug 19, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Shaoqing HeThomas Yorio
Feb 10, 2018·Ophthalmology and Therapy·Adi M Al Owaifeer, Abdulaziz A Al Taisan
Feb 21, 2018·Acta Ophthalmologica·Wishal D Ramdas
Nov 27, 2018·Translational Neuroscience·Qing YangLin Luo
Dec 19, 2018·Current Opinion in Ophthalmology·Claudio I PerezShan Lin
Oct 4, 2020·European Journal of Ophthalmology·Sayena JabbehdariThasarat Sutabutr Vajaranant
Apr 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huan YiLei Zhang
Sep 22, 2017·Diseases·Andrea BraakhuisEhsan Vaghefi
Oct 22, 2020·Nutrients·Annagrazia AdornettoRossella Russo
Sep 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Gary WilliamsonAlan Crozier
Sep 17, 2021·Phytotherapy Research : PTR·Farhad EisvandAbolfazl Shakeri

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