The Effect of Flaxseed in Breast Cancer: A Literature Review

Frontiers in Nutrition
Ana CaladoPaula Ravasco

Abstract

Breast cancer is one of the most common cancers and the second most responsible for cancer mortality worldwide. In 2014, in Portugal approximately 27,200 people died of cancer, of which 1,791 were women with breast cancer. Flaxseed has been one of the most studied foods, regarding possible relations to breast cancer, though mainly in experimental studies in animals, yet in few clinical trials. It is rich in omega-3 fatty acids, α-linolenic acid, lignan, and fibers. One of the main components of flaxseed is the lignans, of which 95% are made of the predominant secoisolariciresinol diglucoside (SDG). SDG is converted into enterolactone and enterodiol, both with antiestrogen activity and structurally similar to estrogen; they can bind to cell receptors, decreasing cell growth. Some studies have shown that the intake of omega-3 fatty acids is related to the reduction of breast cancer risk. In animal studies, α-linolenic acids have been shown to be able to suppress growth, size, and proliferation of cancer cells and also to promote breast cancer cell death. Other animal studies found that the intake of flaxseed combined with tamoxifen can reduce tumor size to a greater extent than taking tamoxifen alone. Additionally, some clinical ...Continue Reading

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Citations

Oct 1, 2020·Food & Function·Giulia DingeoTorsten Bohn
Nov 30, 2018·Physiological Research·L KolátorováL Stárka
May 28, 2019·Nutrients·Mihir ParikhGrant N Pierce
Feb 2, 2021·Frontiers in Chemistry·Yusra Habib KhanAbdullah Salah Alanazi
Aug 17, 2020·Talanta·Camelia Berghian-Grosan, Dana Alina Magdas
May 14, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Mai Mohammad Al-Oqail
Jul 6, 2021·Saudi Journal of Biological Sciences·Zuzana AndrejčákováAlexander V Sirotkin
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tapan BehlDanut-Eugeniu Mosteanu

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