The effect of fluconazole on the clinical pharmacokinetics of methadone

Clinical Pharmacology and Therapeutics
M N CobbP M Rainey

Abstract

A randomized, double-blinded, placebo-controlled pharmacokinetic and safety trial was conducted to determine the effect of fluconazole on methadone disposition. Volunteers receiving methadone maintenance therapy were randomized to receive either 200 mg/day oral fluconazole (n = 13) or placebo (n = 12). After 14 days there was a 35% average increase in serum methadone area under the curve relative to baseline among patients receiving fluconazole (p = 0.0008). At the same time, mean serum methadone peak and trough concentrations increased by 27% (p = 0.0076) and 48% (p = 0.0023), respectively, and oral clearance of methadone was reduced by 24% (p = 0.0007). In contrast, the pharmacokinetics of methadone were unaltered in the placebo group. Renal clearance of methadone was not significantly affected by fluconazole or placebo therapy. Although exposed to increased concentrations of methadone, patients treated with fluconazole did not exhibit signs or symptoms of significant narcotic overdose.

References

Jul 1, 1977·Clinical Pharmacology and Therapeutics·G D BellwardF S Abbott
May 13, 1976·The New England Journal of Medicine·M J KreekL M Giusti
Jan 1, 1990·Pharmacotherapy·S F Kowalsky
Mar 1, 1990·Reviews of Infectious Diseases·J D Lazar, K D Wilner
Apr 1, 1987·Clinical Pharmacology and Therapeutics·C E InturrisiK M Foley
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·V P Dole, M J Kreek
Aug 1, 1973·Journal of Medicinal Chemistry·H R Sullivan, S L Due
Mar 1, 1981·Annals of Internal Medicine·T G TongN L Benowitz
Feb 1, 1994·The Annals of Pharmacotherapy·R M CadleR J Hamill
Oct 1, 1993·Antimicrobial Agents and Chemotherapy·D DeMuriaP H Kazanjian
Sep 13, 1993·Archives of Internal Medicine·A M Baciewicz, F A Baciewicz
Jan 1, 1993·Clinical Pharmacokinetics·D Debruyne, J P Ryckelynck
Oct 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S C PiscitelliH Masur

❮ Previous
Next ❯

Citations

Sep 25, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S M ClarkeD J Back
Mar 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alain H LitwinMarc N Gourevitch
Aug 22, 2009·Journal of Palliative Medicine·Thomas B Strouse
Nov 1, 2006·Antimicrobial Agents and Chemotherapy·Ping LiuAmarnath Sharma
Nov 13, 2004·Postgraduate Medical Journal·R BrownS Reddy
Apr 25, 2001·Journal of Addictive Diseases·E T MoolchanD Epstein
Apr 4, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Douglas J WeschulesSteven Richeimer
Jun 12, 2009·Drug Metabolism Reviews·Shu-Feng ZhouBalram Chowbay
Nov 28, 2006·Expert Opinion on Drug Metabolism & Toxicology·Emilio SternieriAnna Ferrari
Apr 15, 2015·Journal of Analytical Toxicology·David E MoodyWenfang B Fang
Nov 12, 2005·Substance Use & Misuse·Joy C Draper, Elinore F McCance-Katz
Mar 9, 2018·International Journal of Cancer. Journal International Du Cancer·Dirk Theile, Gerd Mikus
Dec 12, 2001·HIV Medicine·S M Clarke, F M Mulcahy
Sep 21, 2004·Human Psychopharmacology·John M CorkeryAdenekan Oyefeso
Feb 23, 2008·Anesthesiology·Rheem A TotahEvan D Kharasch
May 27, 2005·Pharmacoepidemiology and Drug Safety·Ellen C Pearson, Raymond L Woosley
Nov 12, 2009·Clinical Pharmacokinetics·Shu-Feng Zhou
Mar 10, 2000·Clinical Pharmacokinetics·K VenkatakrishnanD J Greenblatt
Apr 22, 2008·Molecular Diagnosis & Therapy·Yongfang LiSiamak Davani
Nov 1, 2011·Critical Reviews in Clinical Laboratory Sciences·Bhushan M KapurPeter Selby
Nov 30, 2018·Current Drug Metabolism·Panjasaram Naidoo, Manoranjenni Chetty
Dec 15, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·P W HugenJ M Lange
Aug 2, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Magang ShouGary L Skiles
Nov 26, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Eirin Bakke, Liliana Bachs

❮ Previous
Next ❯

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