PMID: 9536952Apr 16, 1998Paper

The effect of flufenamic acid on gastrointestinal myoelectrical activity and transit time in dogs

Gut
G FarrugiaJ H Szurszewski

Abstract

Flufenamic acid, a fenamate, has been shown to alter markedly the membrane potential of small intestinal smooth muscle and increase intracellular calcium in single cells. To determine the effects of flufenamic acid on myoelectrical motor activity and gastrointestinal transit in the intact animal. Myoelectrical motor activity was recorded via seromuscular platinum electrodes sutured at regular intervals in the stomach and throughout the small intestine. Fasted and fed gastrointestinal transit was assessed using technetium-99m (99mTc) as the radioactive marker linked to 1 mm amberlite pellets or added to the meal. Flufenamic acid (600 mg, intravenously) induced intense spike activity in the small intestine. The mean duration of irregular spike activity was 250 (7) minutes. Spike activity was more pronounced in the lower small intestine. Flufenamic acid also accelerated initial gastric emptying and markedly shortened transit time in the small intestine. In the fasted state the 50% transit time in the small intestine was 54 (8) minutes with infusion of flufenamic acid compared with 105 (10) minutes in the control group; in the fed state 99mTc first reached the colon at 220 (10) minutes compared with 270 (12) minutes in the control ...Continue Reading

References

Jul 1, 1992·The Journal of Membrane Biology·J L Rae, G Farrugia
Dec 1, 1992·Mayo Clinic Proceedings·M R von der Ohe, M Camilleri
May 1, 1991·Digestive Diseases and Sciences·M CamilleriM Proano
Mar 1, 1974·Journal of Medicinal Chemistry·H TeradaT Fujita
Oct 1, 1980·The Journal of Pharmacy and Pharmacology·G J Sanger, A Bennett

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Citations

Apr 15, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·E MehuysJ P Remon
Sep 3, 2013·Journal of Hepatology·Reiner WiestMarkus Geuking
Apr 20, 2017·International Journal of Molecular Sciences·Filippo MolicaBrenda R Kwak
Oct 5, 2018·Bio-medical Materials and Engineering·Toshiyuki SakuraiChoitsu Sakamoto
Jun 25, 2021·Therapeutic Delivery·Rabab FatimaParteek Prasher

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