PMID: 6110422Sep 15, 1980Paper

The effect of fluroxene [(2,2,2-trifluoroethoxy)ethane] on haem biosynthesis and degradation

The Biochemical Journal
M R ZimanK M Ivanetich

Abstract

Acute fluroxene treatment of male Wistar rats decreases the amounts of hepatic microsomal cytochrome P-450 and haem, increases the activities of hepatic delta-aminolaevulinate synthase and haem oxygenase, and increases the amounts of haem precursors (delta-aminolaevulinate and porphobilinogen) in the urine. All of the above effects of fluroxene are enhanced by pretreatment of the experimental animals with 3-methylcholanthrene and phenobarbital. The amounts of porphyrins in the urine and faeces were generally unaffected by acute fluroxene treatment of uninduced or 3-methylcholanthrene- or phenobarbital-induced Wistar rats. 2,2,2-Trifluoroethyl ethyl ether, the saturated analogue of fluroxene, did not affect the amounts of hepatic cytochrome P-450 and haem, the amounts of any of the haem precursors in the urine or faeces, or the activity of hepatic haem oxygenase in phenobarbital-induced male Wistar rats. The amounts of hepatic cytochrome P-450 and haem and of the haem precursors in urine and faeces, and the activity of delta-aminolaevulinate synthase, were generally not altered by acute fluroxene treatment of uninduced male Long-Evans rats. Chronic treatment of Wistar rats with fluroxene resulted in small increases in the amount...Continue Reading

Citations

Jan 1, 1988·Critical Reviews in Toxicology·L S Kaminsky, J M Fraser
Apr 1, 1997·General Pharmacology·A M BuzalehA M del Carmen Batlle
Dec 1, 1992·Journal of Pharmacological and Toxicological Methods·A M BuzalehA M del Carmen Batlle
Jul 1, 1992·General Pharmacology·A M BuzalehA M Batlle
Oct 1, 1994·General Pharmacology·A M BuzalehA M Batlle

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