The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease

Experimental Neurology
Jessica M CollinsJames C Vickers

Abstract

Traumatic brain injury is a risk factor for Alzheimer's disease (AD), however the effect of such neural damage on the onset and progression of beta-amyloid (Aβ) plaque pathology is not well understood. This study utilized an in vivo model of focal brain injury to examine how localized damage may acutely affect the onset and progression of Aβ plaque deposition as well as inflammatory and synaptic changes, in the APP/PS1 (APPSWE, PSEN1dE9) transgenic model of AD relative to wild-type (Wt) mice. Acute focal brain injury in 3- and 9-month-old APP/PS1 and Wt mice was induced by insertion of a needle into the somatosensory neocortex, as compared to sham surgery, and examined at 24h and 7d post-injury (PI). Focal brain injury did not induce thioflavine-S stained or (pan-Aβ antibody) MOAB-2-labeled plaques at either 24h or 7d PI in 3-month-old APP/PS1 mice or Wt mice. Nine-month-old APP/PS1 mice demonstrate cortical Aβ plaques but focal injury had no statistically significant (p>0.05) effect on thioflavine-S or MOAB-2 plaque load surrounding the injury site at 24h PI or 7d PI. There was a significant (p<0.001) increase in cross-sectional cortical area occupied by Iba-1 positive microglia in injured mice compared to sham animals, howeve...Continue Reading

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Citations

Mar 18, 2016·Acta Neuropathologica Communications·Luisa MöhleIldiko Rita Dunay
Jan 10, 2019·Journal of Neurotrauma·Jessica M CollinsJames C Vickers
Feb 13, 2020·Journal of Neurotrauma·Jessica M CollinsJenna M Ziebell
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Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yaqi YangBen Zhong Tang
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Sep 29, 2019·Journal of Alzheimer's Disease : JAD·Marlena ZyśkAnna Erlandsson
Jun 7, 2017·Scientific Reports·Kimberley E StuartJames C Vickers
Aug 14, 2020·International Journal of Molecular Sciences·Vince SzegeczkiTamás Juhász
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Jun 22, 2018·Neural Regeneration Research·Wen-Juan FanJie-Xin Deng
Jan 8, 2021·Disease Models & Mechanisms·Rachel AtkinsonAnna King

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