The effect of food intake on gene expression in human peripheral blood

Human Molecular Genetics
Amy S LeonardsonEric E Schadt


Human gene expression traits have been shown to be dependent on gender, age and time of day in blood and other tissues. However, other factors that may impact gene expression have not been systematically explored. For example, in studies linking blood gene expression to obesity related traits, whether the fasted or fed state will be the most informative is an open question. Here, we employed a two-arm cross-over design to perform a genome-wide survey of gene expression in human peripheral blood to address explicitly this type of question. We were able to distinguish expression changes due to individual and time-specific effects from those due to food intake. We demonstrate that the transcriptional response to food intake is robust by constructing a classifier from the gene expression traits with >90% accuracy classifying individuals as being in the fasted or fed state. Gene expression traits that were best able to discriminate the fasted and fed states were more heritable and achieved greater coherence with respect to pathways associated with metabolic traits. The connectivity structure among gene expression traits was explored in the context of coexpression networks. Changes in the connectivity structure were observed between ...Continue Reading


May 18, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Mary E WinnNicholas J Schork
Aug 16, 2011·Bioinformatics·Zhengyu OuyangDan Goldowitz
Jul 1, 2010·Genome Medicine·Hélène Choquet, David Meyre
Feb 20, 2010·PLoS Computational Biology·Jun ZhuEric E Schadt
Jul 18, 2014·PloS One·Anastasia V ShindyapinaYuri L Dorokhov
Feb 7, 2014·Nucleic Acids Research·Sungwon Jung, Seungchan Kim
Jan 24, 2012·Biochemical and Biophysical Research Communications·Seiji NakamuraKenichi Matsubara
May 17, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Arlan G Richardson, Eric E Schadt
May 9, 2008·PLoS Biology·Eric E SchadtRoger Ulrich
Dec 15, 2010·PLoS Computational Biology·Benjamin A Logsdon, Jason Mezey
Sep 29, 2011·PloS One·Weiliang QiuECLIPSE Investigators
Apr 14, 2010·PLoS Computational Biology·Enrico PetrettoSylvia Richardson
Jan 13, 2010·PLoS Genetics·Timothy B SacktonAndrew G Clark
Oct 17, 2009·PloS One·Colton LinnertzOrnit Chiba-Falek
Sep 17, 2010·PLoS Genetics·Michael InouyeLeena Peltonen
Sep 14, 2011·PloS One·Radu DobrinValur Emilsson
Sep 9, 2015·PloS One·Kuo-Ching LiangKenta Nakai


May 12, 1998·The American Journal of Physiology·L A Scheving, W Gardner
Dec 11, 1999·Nature·L H HartwellA W Murray
Jan 2, 2001·The Journal of Biological Chemistry·B Amir-Ahmady, L M Salati
Apr 19, 2002·Chronobiology International·Philippe BourinFrancis Lévi
Aug 31, 2002·Science·E RavaszA L Barabási
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Adeline R WhitneyPatrick O Brown
Dec 19, 2003·Nucleic Acids Research·Minoru KanehisaMasahiro Hattori
Jan 22, 2004·Nature Reviews. Genetics·Albert-László Barabási, Zoltán N Oltvai
Apr 6, 2004·Science·Shirly PintoTamas L Horvath
Jun 5, 2004·Genomics·Jerald P RadichPeter S Linsley
Jun 25, 2004·American Journal of Respiratory and Critical Care Medicine·Todd M BullMark W Geraci
Aug 17, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Violeta RusCharles S Via
Aug 28, 2004·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hisato KobayashiNorio Ishida
Nov 30, 2004·Science·Insuk LeeEdward M Marcotte
Apr 19, 2005·Obesity Research·Leonie K HeilbronnEric Ravussin
Jun 4, 2005·Clinical and Experimental Immunology·T TanakaT Hara
Jul 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·F BoroveckiD Krainc
Aug 4, 2005·Science's STKE : Signal Transduction Knowledge Environment·Eric E SchadtStephen Friend
Aug 27, 2005·World Journal of Gastroenterology : WJG·Shi-Yan YuZheng-Hong Yuan
Oct 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stephen J GlattMing T Tsuang
Mar 18, 2008·Nature·Valur EmilssonKari Stefansson
Mar 18, 2008·Nature·Yanqing ChenEric E Schadt

Related Concepts

Metabolic Process, Cellular
Biochemical Pathway
Peripheral Blood
Transcription, Genetic
Gene Expression
Receiver Operating Characteristic
Quantitative Trait, Heritable
In Blood

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