PMID: 8584481Oct 1, 1995Paper

The effect of food on pharmacokinetics of zalcitabine in HIV-positive patients

Pharmaceutical Research
L A NazarenoJ Massarella

Abstract

The purpose of this study was to determine the effect of food on the pharmacokinetics of zalcitabine in HIV-positive patients. Twenty patients received single oral 1.5 mg doses of zalcitabine with and without a standard breakfast in an open-label, randomized crossover study with at least a one week washout period between treatments. Serial blood and urine samples were collected over 24 hours and assayed for zalcitabine by a modified GC/MS method. Administration with food delayed and prolonged absorption resulting in a decrease of approximately 39% in maximal plasma concentrations compared to dosing under fasting conditions. Comparison of plasma AUC values indicated a small (14%) reduction in bioavailability when given with food. Approximately 59% and 45% of the dose were excreted unchanged in the urine under fasting and fed conditions, respectively. The results of this study show that the administration of zalcitabine with food results in a mild reduction in bioavailability. Although these changes are not expected to be of clinical importance, further studies must be conducted for confirmation.

Citations

Jun 5, 2002·Journal of Clinical Pharmacology·Patrick F SmithCharles H Ballow
Jul 3, 2002·Drugs·Lars E Schmidt, Kim Dalhoff
Mar 27, 2007·Pharmaceutical Research·Chong-Hui GuRonald L Smith
May 23, 1998·Journal of Clinical Pharmacology·M BazungaJ Massarella
Apr 4, 2006·Molecular Immunology·Andrew Franklin, Robert V Blanden

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