PMID: 3757164Jan 1, 1986Paper

The effect of food on the oral administration of 6-mercaptopurine

Cancer Chemotherapy and Pharmacology
N K BurtonT A Lister

Abstract

The effect of food on the bioavailability of 6-mercaptopurine (6-MP) has been investigated. Seven patients were studied on two separate occasions. On the first occasion 6-MP was administered p.o. after an overnight fast and on the second, 15 min after a standard breakfast. 6-MP concentrations were determined by high-performance liquid chromatography. Variable plasma drug levels were observed between individual subjects in the fasting state. The peak levels of 6-MP were lower and took longer to be achieved following administration after a standard breakfast than after an overnight fast. In two subjects levels were undetectable (less than 20 ng/ml). In view of these observations it is suggested that 6-MP should be administered before food if maximum blood levels are to be achieved.

References

Jan 1, 1985·Cancer Chemotherapy and Pharmacology·A D PearsonA N Campbell
Oct 27, 1984·British Medical Journal·C F George
Oct 1, 1983·British Journal of Clinical Pharmacology·L LennardJ L Maddocks
Jan 1, 1984·Advances in Experimental Medicine and Biology·T J SchoutenG A De Vaan
Jan 1, 1984·Cancer Chemotherapy and Pharmacology·A G Bosanquet, E D Gilby

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Citations

Mar 1, 1996·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·E SchützM Oellerich
Jul 3, 2002·Drugs·Lars E Schmidt, Kim Dalhoff
Nov 23, 2013·Pediatric Blood & Cancer·Kim K B ClemmensenUNKNOWN Nordic Society of Pediatric Hematology, Oncology (NOPHO)
Mar 25, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wendy LandierSmita Bhatia
Nov 30, 2007·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Mário L de LemosTanya Leduc
Jan 1, 1989·Pediatric Hematology and Oncology·G LönnerholmU Myrdal
Sep 9, 2004·Alimentary Pharmacology & Therapeutics·T StevensB Lashner
Sep 1, 1988·Annals of Clinical Biochemistry·J L RudyP Van Dreal
Jan 2, 1989·The Medical Journal of Australia·P J Neuvonen, K T Kivistö
Jan 1, 1991·Baillière's Clinical Haematology·R L CapizziD J Fernandes
Sep 7, 2021·European Journal of Drug Metabolism and Pharmacokinetics·Ahmed B BayoumyNanne K H de Boer
Jan 1, 1989·Medical Oncology and Tumor Pharmacotherapy·P LafolieC Peterson
Jan 1, 1991·Medical Oncology and Tumor Pharmacotherapy·R HenrikssonK Grankvist

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