PMID: 10775819Apr 25, 2000Paper

The effect of FR167653 on pulmonary ischemia-reperfusion injury in rats

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Y OtaniY Morishita

Abstract

A novel synthesized organic compound, FR167653, has been characterized as a potent suppressant of interleukin-1 and tumor necrosis factor-alpha. We designed this experimental study to evaluate the effect of FR167653 on ischemia-reperfusion injury of the rat lung. Following general anesthesia, the left bronchus, pulmonary artery and vein were clamped for 1 hour. FR167653 was administered continuously beginning 30 minutes before the onset of ischemia and extending for 2 hours after reperfusion. Thirty-eight Wistar rats were divided into 4 groups according to the dose of FR167653 at the rate of 0.1, 0.05 and 0.025 mg/kg/hr in each group. After the optimal dose was obtained from the result of 1-week survival rate, the group with the optimal dose was compared with a control group by using such parameters as arterial oxygen saturation (SaO(2)), arterial oxygen tension (PaO(2)), cytokines, the expression of p38 MAP kinase and histologic study. Survival rate of the group received FR at the rate of 0.1 mg/kg/hr (FR0.1 group) was best among the 4 groups. SaO(2) levels and PaO(2) levels after 2-hour of reperfusion were significantly (p < 0.05, respectively) higher in the FR0.1 group than in the control group. After 2-hour reperfusion, IL-...Continue Reading

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Citations

Dec 20, 2000·Transplantation Proceedings·Y SunoseY Morishita
Aug 21, 2003·Burns : Journal of the International Society for Burn Injuries·Xu-Lin ChenGuang-Qing Wang
Sep 29, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M AibaY Morishita
May 10, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Y KawashimaY Morishita
Jun 21, 2002·Surgery·Hidehisa KitadaMasao Tanaka
Jan 9, 2004·American Journal of Respiratory and Critical Care Medicine·Jiangping DengRobert A Star
Apr 29, 2014·The Journal of Surgical Research·Nassim FardArianeb Mehrabi
Dec 12, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M J BownR D Sayers
Aug 14, 2015·Acta Cirúrgica Brasileira·Marlon Roberto FiorentiniCarlos Otávio Corso
Apr 17, 2002·Shock·Koroush KabirReuven Rabinovici
Jun 6, 2008·American Journal of Physiology. Renal Physiology·Dong-Sub JungShin-Wook Kang
Jan 14, 2021·Transplantation Direct·Tara TalaieChristine L Lau

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