The effect of frusemide on water and electrolyte absorption from the human jejunum

Clinical Science and Molecular Medicine
J F MacKenzieR I Russell


1. Frusemide, in a dose of 120 nmol (40 mg) administered intravenously, significantly reduced the absorption of water and electrolytes from the human jejunum, a double-lumen perfusion system with proixmal occluding balloons being used. Net secretion of water and electrolytes occurred in some subjects. 2. No significant change in water and electrolyte absorption was observed with 60 nmol (20 mg) of frusemide. 3. These findings may explain the diarrhoea which may be induced by fursemide in some patients.


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Related Concepts

Salix - substance
Intestinal Absorption
Water-Electrolyte Balance

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