The effect of gamma-tocopherol on proliferation, integrin expression, adhesion, and migration of human glioma cells

Biochemical and Biophysical Research Communications
Elika SamandariAngelo Azzi

Abstract

The effect of vitamin E on proliferation, integrin expression, adhesion, and migration in human glioma cells has been studied. gamma-tocopherol at 50 microM concentration exerted more inhibitory effect than alpha-tocopherol at the same concentration on glioma cell proliferation. Integrin alpha5 and beta1 protein levels were increased upon both alpha- and gamma-tocopherol treatments. In parallel, an increase in the alpha5beta1 heterodimer cell surface expression was observed. The tocopherols inhibited glioma cell-binding to fibronectin where gamma-tocopherol treatment induced glioma cell migration. Taken together, the data reported here are consistent with the notion that the inhibition of glioma cell proliferation induced by tocopherols may be mediated, at least in part, by an increase in integrin alpha5 and beta1 expression. Cell adhesion is also negatively affected by tocopherols, despite a small increase in the surface appearance of the alpha5beta1 heterodimer. Cell migration is stimulated by gamma-tocopherol. It is concluded that alpha5 and beta1 integrin expression and surface appearance are not sufficient to explain all the observations and that other integrins or in general other factors may be associated with these events.

References

Feb 17, 1999·Frontiers in Bioscience : a Journal and Virtual Library·J H UhmJ S Rao
Sep 6, 2002·The Journal of Cell Biology·R C Liddington, M H Ginsberg
Oct 9, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·René GysinTheresa Visarius
Mar 15, 2003·Nature Reviews. Cancer·John D Hood, David A Cheresh
Aug 15, 2003·World Journal of Gastroenterology : WJG·Yu-Long LiangXi-Liang Zha

❮ Previous
Next ❯

Citations

Sep 15, 2009·Carcinogenesis·Jihyeung JuChung S Yang
Jul 20, 2012·Journal of the National Cancer Institute·Wei ZhangYong-Bing Xiang
May 13, 2011·Journal of Clinical Biochemistry and Nutrition·Shunsuke YoshidaKazumi Yagasaki
Sep 23, 2008·Molecular and Cellular Neurosciences·Katrin FärberHelmut Kettenmann
Jun 15, 2007·Free Radical Biology & Medicine·Angelo Azzi
May 20, 2008·Free Radical Research·Jean-Francois LandrierPatrick Borel
Jul 29, 2008·Bioorganic & Medicinal Chemistry·Stephan OhnmachtJeffrey Atkinson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.